Martijn A. Langereis

TL;DR: The crystal structure of a coronavirus (CoV) HE in complex with its receptor is reported and the plasticity of the CoV HE receptor-binding site is attributed to evolutionary flexibility conferred by functional redundancy between HE and its companion spike protein S.

TL;DR: This study dissected the IFN-α/β-stimulatory activity of different viral RNA species produced during picornavirus infection, both by RNA transfection and in infected cells in which specific steps of viral RNA replication were inhibited.

TL;DR: A critical role of 2Apro is identified by cleaving MDA5 and MAVS and shows that enteroviruses use a common strategy to counteract the interferon response in infected cells.

TL;DR: It is shown that cellular infection with MERS-CoV does not lead to the formation of SGs and that p4a suppressing the PKR-dependent stress response pathway, probably by sequestering dsRNA.

TL;DR: It is demonstrated here that ISRIB inhibits low-level ISR activity, but does not affect strong ISR signaling, and the effects of pharmacological activation of eIF2B are tuned by P-eIF2α concentration, which provides a plausible mechanism of howISRIB counteracts toxic chronic ISRactivity, without disturbing the cytoprotective effects of a strong acute ISR.