Jana Havlíčková

TL;DR: For application in positron emission tomography (PET), PrP9, a N,N',N''-trisubstituted triazacyclononane with methyl(2-carboxyethyl)phosphinic acid pendant arms, was developed as (68)Ga(3+) complexing agent, which for the first time can be directly used for labeling purposes.

TL;DR: The kinetic inertness of both chelates is extremely high and approves the application of Ga(3+) complexes of such DOTA-like ligands in molecular imaging.

TL;DR: Complex formation studies in acidic solutions indicate that Ga(3+) complexes of the phosphinate ligands are formed quickly (minutes) and quantitatively even at pH <2.5, and the discussed TRAP ligANDs are suitable alternatives for the development of (68)Ga radiopharmaceuticals.

TL;DR: A surprisingly high value of the last DOTA dissociation constant was determined by potentiometry and confirmed by using NMR spectroscopy, suggesting that DOTA and its derivatives seem to be very suitable ligands for scandium radioisotopes.

TL;DR: A new class of macrocyclic ligands based on 1-oxa-4,7-diazacyclononane was synthesized and their Mn(2+) complexes were investigated with respect to stability and relaxation properties, revealing a relatively low thermodynamic stability of the Mn( 2+) complexes with all ligands investigated.