V
Vojtěch Kubíček
Researcher at Charles University in Prague
Publications - 62
Citations - 2087
Vojtěch Kubíček is an academic researcher from Charles University in Prague. The author has contributed to research in topics: DOTA & Phosphinate. The author has an hindex of 23, co-authored 57 publications receiving 1864 citations. Previous affiliations of Vojtěch Kubíček include Delft University of Technology & Centre national de la recherche scientifique.
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Journal ArticleDOI
Gadolinium(III) complexes as MRI contrast agents: ligand design and properties of the complexes
TL;DR: The ligand types and structures of their complexes on one side and a set of the physico-chemical parameters governing properties of the CAs on the other side are discussed and the solid-state structures of lanthanide(III) complexes of open-chain and macrocyclic ligands and their structural features are compared.
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A Triazacyclononane‐Based Bifunctional Phosphinate Ligand for the Preparation of Multimeric 68Ga Tracers for Positron Emission Tomography
Johannes Notni,Johannes Notni,Petr Hermann,Jana Havlíčková,Jan Kotek,Vojtěch Kubíček,Jan Plutnar,Natalia Loktionova,Patrick J. Riss,Frank Rösch,Ivan Lukeš +10 more
TL;DR: For application in positron emission tomography (PET), PrP9, a N,N',N''-trisubstituted triazacyclononane with methyl(2-carboxyethyl)phosphinic acid pendant arms, was developed as (68)Ga(3+) complexing agent, which for the first time can be directly used for labeling purposes.
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Gallium(III) complexes of DOTA and DOTA-monoamide: kinetic and thermodynamic studies.
TL;DR: The kinetic inertness of both chelates is extremely high and approves the application of Ga(3+) complexes of such DOTA-like ligands in molecular imaging.
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Complexation of metal ions with TRAP (1,4,7-triazacyclononane phosphinic acid) ligands and 1,4,7-triazacyclononane-1,4,7-triacetic acid: phosphinate-containing ligands as unique chelators for trivalent gallium.
Jakub Šimeček,Martin Schulz,Johannes Notni,Jan Plutnar,Vojtěch Kubíček,Jana Havlíčková,Petr Hermann +6 more
TL;DR: Complex formation studies in acidic solutions indicate that Ga(3+) complexes of the phosphinate ligands are formed quickly (minutes) and quantitatively even at pH <2.5, and the discussed TRAP ligANDs are suitable alternatives for the development of (68)Ga radiopharmaceuticals.
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PET/CT imaging of osteoblastic bone metastases with (68)Ga-bisphosphonates: first human study.
Marco Fellner,Richard P. Baum,Vojtěch Kubíček,Petr Hermann,Ivan Lukeš,Vikas Prasad,Frank Rösch +6 more
TL;DR: [Ga]BPAMD seems to be an ideal PET/CT tracer to plan and monitor bisphosphonate therapy in several bone disorders like osteoporosis, osteitis deformans, bone metastases, multiple myeloma, osteogenesis imperfecta, etc. and also to monitor radionuclide therapy for palliation of bone pain.