Jana Stepankova

TL;DR: complexes with arene = tha, thn, dha, ind and p-terp, and deprotonated bipyridinediol (bipy(OH)O) as chelating ligands, exhibited significant cytotoxicity toward A2780 human ovarian and A549 human lung cancer cells.

TL;DR: Flow cytometric studies and impedance-based monitoring of cellular responses to 1 demonstrated that 1 acts more quickly than cisplatin to induce cell death and that 1 is a more effective apoptosis inducer than cis platin in particular in early stages of treatment, when the apoptotic effects predominate over necrosis.

TL;DR: The observation that major DNA adducts of photo activated 1 are able to efficiently stall RNA polymerase II more efficiently than cisplatin suggests that transcription inhibition may contribute to the cytotoxicity levels observed for photoactivated 1.

TL;DR: The results indicate that the enhanced cytotoxicity of the Pt(IV)-VPA conjugates is a consequence of several processes involving enhanced cellular accumulation, downregulation of HDACs and yet other biochemical processes (not involvingHDACs) which may potentiate antitumor effects.

TL;DR: New platinum(IV) derivatives of oxaliplatin conjugated with valproic acid (VPA) seem to be promising dual-targeting candidates for additional preclinical studies and demonstrate the dual targeting strategy to be a valuable route to pursue in the design of platinum agents.