Journal ArticleDOI
The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes
Tijana Bugarcic,Abraha Habtemariam,Jana Stepankova,Pavla Heringova,Jana Kasparkova,Robert J. Deeth,Russell D. L. Johnstone,Alessandro Prescimone,Andrew Parkin,Simon Parsons,Viktor Brabec,Peter J. Sadler +11 more
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TLDR
complexes with arene = tha, thn, dha, ind and p-terp, and deprotonated bipyridinediol (bipy(OH)O) as chelating ligands, exhibited significant cytotoxicity toward A2780 human ovarian and A549 human lung cancer cells.Abstract:
The synthesis and characterization of ruthenium(II) arene complexes [(η6-arene)Ru(N,N)Cl]0/+, where N,N = 2,2′-bipyridine (bipy), 2,2′-bipyridine-3,3′-diol (bipy(OH)2) or deprotonated 2,2′-bipyridine-3,3′-diol (bipy(OH)O) as N,N-chelating ligand, arene = benzene (bz), indan (ind), biphenyl (bip), p-terphenyl (p-terp), tetrahydronaphthalene (thn), tetrahydroanthracene (tha) or dihydroanthracene (dha), are reported, including the X-ray crystal structures of [(η6-tha)Ru(bipy)Cl][PF6] (1), [(η6-tha)Ru(bipy(OH)O)Cl] (2) and [(η6-ind)Ru(bipy(OH)2)Cl][PF6] (8). Complexes 1 and 2 exibit CH (arene)/π (bipy or bipy(OH)O) interactions. In the X-ray structure of protonated complex 8, the pyridine rings are twisted (by 17.31°). In aqueous solution (pH = 2−10), only deprotonated (bipy(OH)O) forms are present. Hydrolysis of the complexes was relatively fast in aqueous solution (t1/2 = 4−15 min, 310 K). When the arene is biphenyl, initial aquation of the complexes is followed by partial arene loss. Complexes with arene =...read more
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Journal ArticleDOI
Arene ruthenium complexes as anticancer agents
TL;DR: Neutral or cationic arene ruthenium complexes providing both hydrophilic as well as hydrophobic properties due to the robustness of the rUThenium-arene unit hold a high potential for the development of metal-based anticancer drugs.
Journal ArticleDOI
Organometallic Half-Sandwich Iridium Anticancer Complexes
Zhe Liu,Abraha Habtemariam,Ana M. Pizarro,Sally A. Fletcher,Anna Kisova,Oldrich Vrana,Luca Salassa,Pieter C. A. Bruijnincx,Guy J. Clarkson,Viktor Brabec,Peter J. Sadler +10 more
TL;DR: The hydrophobicity and intercalative ability of Cp (xph) and Cp(xbiph) make a major contribution to the anticancer potency of their Ir(III) complexes.
Book ChapterDOI
Activation Mechanisms for Organometallic Anticancer Complexes
TL;DR: In this article, the activation of metallocenes, arene, alkyl or aryl complexes by hydrolysis, and metal- or ligand-based redox reactions is discussed.
Journal ArticleDOI
DNA Binding and Anti-Cancer Activity of Redox-Active Heteroleptic Piano-Stool Ru(II), Rh(III), and Ir(III) Complexes Containing 4-(2-Methoxypyridyl)phenyldipyrromethene
Rakesh Kumar Gupta,Rampal Pandey,Gunjan Sharma,Ritika Prasad,Biplob Koch,Saripella Srikrishna,Pei-Zhou Li,Qiang Xu,Daya Shankar Pandey +8 more
TL;DR: The results suggest that in vitro antitumor activity of 1-4 lies in the order 2 > 1 > 4 > 3.
Journal ArticleDOI
Anticancer activity of multinuclear arene ruthenium complexes coordinated to dendritic polypyridyl scaffolds
Preshendren Govender,Nathan C. Antonels,Johan Mattsson,Anna K. Renfrew,Paul J. Dyson,John R. Moss,Bruno Therrien,Gregory S. Smith +7 more
TL;DR: The rational development of multinuclear arene ruthenium complexes (arene = p-cymene, hexamethylbenzene) from generation 1 (G1) and generation 2 (G2) of 4-iminopyridyl based poly(propyleneimine) dendrimer scaffolds of the type DAB-(NH2)n (n = 4 or 8, DAB = diaminobutane) has been accomplished in order to exploit the enhanced permeability and retention' (EPR) effect that allows
References
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A critical account on π–π stacking in metal complexes with aromatic nitrogen-containing ligands
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Journal ArticleDOI
Relativistic regular two‐component Hamiltonians
TL;DR: In this article, potential-dependent transformations are used to transform the four-component Dirac Hamiltonian to effective two-component regular Hamiltonians, which already contain the most important relativistic effects, including spin-orbit coupling.