Tijana Bugarcic

TL;DR: The synthesis and characterization of ruthenium(II) arene complexes of the general formula [(eta(6)-arene)Ru(XY)Z](+) are reported and the relationship between the cytotoxic activity and the solution and solid state structures of the imine and amine complexes is discussed.

TL;DR: Circular and linear dichroism, competitive binding experiments with ethidium bromide, DNA melting, and surface-enhanced Raman spectroscopic data are consistent with combined intercalative and monofunctional (coordination) binding mode of complex 1, and this unusual DNA binding mode may make a major contribution to the high potency ofcomplex 1.

TL;DR: complexes with arene = tha, thn, dha, ind and p-terp, and deprotonated bipyridinediol (bipy(OH)O) as chelating ligands, exhibited significant cytotoxicity toward A2780 human ovarian and A549 human lung cancer cells.

TL;DR: Ion mobility-mass spectrometry combined with molecular modeling was used for the separation and configurational analysis of three low-molecular-weight isomeric organoruthenium anticancer complexes containing ortho-, meta-, or para-terphenyl arene ligands.

TL;DR: The view that monodentate Ru(II) arene complexes belong to a class of anticancer agents for which structure-pharmacological relationships might be correlated with their DNA-binding modes is supported.