J
Jane E. Ishmael
Researcher at Oregon State University
Publications - 49
Citations - 7143
Jane E. Ishmael is an academic researcher from Oregon State University. The author has contributed to research in topics: Myosin & Myosin light-chain kinase. The author has an hindex of 20, co-authored 44 publications receiving 6521 citations. Previous affiliations of Jane E. Ishmael include University of Maryland, Baltimore & Oregon Health & Science University.
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Journal ArticleDOI
Depsipeptide Companeramides from a Panamanian Marine Cyanobacterium Associated with the Coibamide Producer
Oliver B. Vining,Rebecca A. Medina,Edward A. Mitchell,Patrick Videau,Dong Li,Jeffrey D. Serrill,Jane X. Kelly,William H. Gerwick,Philip Proteau,Jane E. Ishmael,Kerry L. McPhail +10 more
TL;DR: Two new cyclic depsipeptides, companeramides A (1) and B (2) showed high nanomolar in vitro antiplasmodial activity but were not overtly cytotoxic to four human cancer cell lines at the doses tested.
Journal ArticleDOI
Direct interaction of myosin regulatory light chain with the NMDA receptor.
David Amparan,Dorina Avram,Christopher G. Thomas,Michaela G. Lindahl,Jing Yang,Gaurav Bajaj,Jane E. Ishmael +6 more
TL;DR: Myosin RLC–NMDA receptor interactions may contribute to the contractile and motile forces that are placed upon NMDA receptor subunits during changes associated with synaptic plasticity and neural morphogenesis.
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Coibamide A, a natural lariat depsipeptide, inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts
Jeffrey D. Serrill,Xuemei Wan,Andrew M. Hau,Hyo Sang Jang,Daniel J. Coleman,Arup K. Indra,Adam W.G. Alani,Kerry L. McPhail,Jane E. Ishmael +8 more
TL;DR: Comparisons between coibamide A- and apratoxin A-induced changes in cell morphology, decreases in VEGFR2 expression and macroautophagy signaling in HUVECs raise the possibility that both cyanobacterial natural products share a common mechanism of action.
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Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins
Dale Tranter,Anja O. Paatero,Shinsaku Kawaguchi,Soheila Kazemi,Jeffrey D. Serrill,Juho Kellosalo,Walter K. Vogel,Uwe Richter,Daphne R. Mattos,Xuemei Wan,Christopher C. Thornburg,Shinya Oishi,Kerry L. McPhail,Jane E. Ishmael,Ville O. Paavilainen +14 more
TL;DR: This work connecting CbA activity with selective prevention of secretory and membrane protein biogenesis by inhibition of Sec61 opens up possibilities for developing new Sec61 inhibitors with improved drug-like properties that are based on the coibamide pharmacophore.
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Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2
Dorina Avram,Jane E. Ishmael,Daniel J. Nevrivy,Valerie J. Peterson,Suk-Hyung Lee,Paul Dowell,Mark Leid +6 more
TL;DR: It is demonstrated that ARP1 and Ear2 form heterodimers in solution and on directly repeated response elements with high efficiency and a specificity differing from that of homodimeric complexes composed of either receptor.