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Uwe Richter
Researcher at University of Helsinki
Publications - 26
Citations - 1112
Uwe Richter is an academic researcher from University of Helsinki. The author has contributed to research in topics: RNA & Mitochondrion. The author has an hindex of 16, co-authored 25 publications receiving 810 citations. Previous affiliations of Uwe Richter include Humboldt State University & Newcastle University.
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Journal ArticleDOI
Phage-Type RNA Polymerase RPOTmp Performs Gene-Specific Transcription in Mitochondria of Arabidopsis thaliana
Kristina Kühn,Uwe Richter,Etienne H. Meyer,Etienne Delannoy,Andéol Falcon de Longevialle,Nicholas O'Toole,Thomas Börner,A. Harvey Millar,Ian Small,James Whelan +9 more
TL;DR: The transcriptional role of the dual-targeted RNA polymerase in mitochondria of Arabidopsis thaliana is characterized and altered transcript levels in rpoTmp were found to result from gene-specific transcriptional changes, establishing that RPOTmp functions in distinct transcriptional processes within mitochondria.
Journal ArticleDOI
Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions
Saara Forsström,Christopher B. Jackson,Christopher Carroll,Christopher Carroll,Mervi Kuronen,Eija Pirinen,Swagat Pradhan,Anastasiia Marmyleva,Mari Auranen,Iida-Marja Kleine,Nahid Akhtar Khan,Anne Roivainen,Päivi Marjamäki,Heidi Liljenbäck,Liya Wang,Brendan J. Battersby,Uwe Richter,Vidya Velagapudi,Joni Nikkanen,Liliya Euro,Anu Suomalainen,Anu Suomalainen +21 more
TL;DR: The evidence indicates that FGF21 is a local and systemic messenger of mtDNA stress in mice and humans with mitochondrial disease, and drives weight loss and glucose preference, and modifies metabolism and respiratory chain deficiency in a specific hippocampal brain region.
Journal ArticleDOI
A mitochondrial ribosomal and RNA decay pathway blocks cell proliferation.
Uwe Richter,Taina Lahtinen,Paula Marttinen,Maarit Myöhänen,Dario Greco,Giuseppe Cannino,Howard T. Jacobs,Niina Lietzén,Tuula A. Nyman,Brendan J. Battersby +9 more
TL;DR: This work demonstrates that one class of antiproliferative antibiotic induces stalled mitochondrial ribosomes, which triggers a mitochondrial ribOSome and RNA decay pathway, which constitutes an important organelle checkpoint for cell division.
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Two RpoT genes of Physcomitrella patens encode phage-type RNA polymerases with dual targeting to mitochondria and plastids
Uwe Richter,Justine Kiessling,Boris Hedtke,Eva L. Decker,Ralf Reski,Thomas Börner,Andreas Weihe +6 more
TL;DR: The two genes result from a gene duplication event that occurred independently from the one which led to the organellar polymerases with mitochondrial or plastid targeting properties in angiosperms, and are representatives of the molecular evolutionary line leading to the RpoT genes of higher land plants.
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Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness
TL;DR: Impaired turnover of newly synthesized mitochondrial proteins of the oxidative phosphorylation complexes leads to protein over-accumulation in the inner mitochondrial membrane, thereby generating a stress that dissipates the mitochondrial membrane potential and therefore compromises organelle and cellular fitness.