J
Jane Somsel Rodman
Researcher at Washington University in St. Louis
Publications - 13
Citations - 1543
Jane Somsel Rodman is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Endosome & Glycoprotein. The author has an hindex of 11, co-authored 13 publications receiving 1525 citations.
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Journal ArticleDOI
Evidence for receptor-mediated binding of glycoproteins, glycoconjugates, and lysosomal glycosidases by alveolar macrophages.
TL;DR: The results suggest the presence of a cell surface receptor on alveolar macrophages that binds glycoproteins having terminal sugars with the mannose or glucose configuration.
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Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: Characterization and evidence for receptor recycling
TL;DR: The results, taken together with the observation that cycloheximide has no effect on ligand uptake, suggest that receptors must be spared from degradation and that reutilization of receptors probably occurs.
Journal ArticleDOI
Evidence for specific recognition sites mediating clearance of lysosomal enzymes in vivo
Philip D. Stahl,Howard Six,Jane Somsel Rodman,Paul H. Schlesinger,Daulat R.P. Tulsiani,Oscar Touster +5 more
TL;DR: The results suggest that specific recognition sites occur on lysosomal hydrolases which mediate clearance following intravenous injection, and that these sites involve the carbohydrate portions of the enzymes.
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Recognition of lysosomal glycosidases in vivo inhibited by modified glycoproteins.
TL;DR: A modified plasma glycoprotein terminating in N-acetyl-glucosamine has been shown to inhibit recognition and clearance of several purified lysosomal glycosidases.
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Clearance of lysosomal hydrolases following intravenous infusion: The role of liver in the clearance of β-glucuronidase and N-acetyl-β-d-glucosaminidase
TL;DR: Results indicate that β-glucuronidase, N -acetyl-β- d -glucosaminidases, and probably other glycosidases are rapidly incorporated into the lysosomal compartment of liver.