Journal ArticleDOI
Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: Characterization and evidence for receptor recycling
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TLDR
The results, taken together with the observation that cycloheximide has no effect on ligand uptake, suggest that receptors must be spared from degradation and that reutilization of receptors probably occurs.About:
This article is published in Cell.The article was published on 1980-01-01. It has received 543 citations till now. The article focuses on the topics: Ligand (biochemistry) & Receptor recycling.read more
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Tolerogenic dendritic cells.
TL;DR: It is suggested that several clinical situations, including autoimmunity and certain infectious diseases, can be influenced by the antigen-specific tolerogenic role of DCs.
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Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.
TL;DR: The capacity of DCs to capture and process antigen could be modulated by exogenous stimuli was investigated and it was found that DCs respond to tumor necrosis factor alpha, CD40 ligand, IL-1, and lipopolysaccharide with a coordinate series of changes that include downregulation of macropinocytosis and Fc receptors, disappearance of the class II compartment, and upregulation of adhesion and costimulatory molecules.
Journal ArticleDOI
Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation.
TL;DR: Recombinant murine IL-4 is established as a potent and selective enhancer of murine MMR activity in vitro and induces inflammatory macrophages to adopt an alternative activation phenotype, distinct from that induced by IFN-gamma.
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Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
TL;DR: The data suggest that transferrin is internalized via coated pits and vesicles and demonstrate thatTransferrin and its receptor are recycled back to the plasma membrane after endocytosis, and are shown to be lysosomal in nature.
Journal ArticleDOI
Endocytosis and the recycling of plasma membrane.
TL;DR: This article centers on the properties and dynamics of the endocytic vacuole membrane and stresses observations on cultured mouse macrophages with which the authors are most familier.
References
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Journal ArticleDOI
The Attractions of Proteins for Small Molecules and Ions
TL;DR: The number and variety of known compounrjs between proteins and small molecules are increasing rapidly and make a fascinating story as discussed by the authors, and there are many compounds of serum albumin, which was used during the war by many chemists, most of whom found at least one 6ew compound.
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The preparation of 131i-labelled human growth hormone of high specific radioactivity
TL;DR: The loss of immunological reactivity at high specific radioactivities or at high levels of chemical substitution with STAI/sup 127/!iodine is demonstrated.
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125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.
TL;DR: The data are consistent with a mechanism in which 125I-hEGF initially is bound to the cell surface and subsequently is internlized before degradation, and the binding capacity of these cells is restored by incubation in a serum-containing medium.
Book ChapterDOI
The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins.
Gilbert Ashwell,Anatol G. Morell +1 more
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