P
Paul H. Schlesinger
Researcher at Washington University in St. Louis
Publications - 168
Citations - 15359
Paul H. Schlesinger is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Osteoclast & Lipid bilayer. The author has an hindex of 57, co-authored 167 publications receiving 14491 citations. Previous affiliations of Paul H. Schlesinger include National Institutes of Health & University of Washington.
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Journal ArticleDOI
Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase
Sheila Sturgill-Koszycki,Paul H. Schlesinger,Prasanta Chakraborty,Pryce L. Haddix,Helen L. Collins,Agnes K. Fok,Richard D. Allen,Stephen L. Gluck,John E. Heuser,David G. Russell +9 more
TL;DR: Immunoelectron microscopy of infected macrophages and immunoblotting of isolated phagosomes showed that Mycobacterium vacuoles acquire the lysosomal membrane protein LAMP-1, but not the vesicular proton-adenosine triphosphatase (ATPase) responsible for phagosomal acidification.
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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.
Stanley J. Korsmeyer,Michael C. Wei,Michael C. Wei,Mitsuyoshi Saito,Solly Weiler,Kyoung Joon Oh,Paul H. Schlesinger +6 more
TL;DR: An activation cascade of pro-apoptotic proteins from BID to BAK or BAX integrates the pathway from surface death receptors to the irreversible efflux of cytochrome c.
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Evidence for receptor-mediated binding of glycoproteins, glycoconjugates, and lysosomal glycosidases by alveolar macrophages.
TL;DR: The results suggest the presence of a cell surface receptor on alveolar macrophages that binds glycoproteins having terminal sugars with the mannose or glucose configuration.
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Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance
Donald J. Krogstad,Ilya Y. Gluzman,Dennis E. Kyle,Ayoade M.J. Oduola,Samuel K. Martin,Wilbur K. Milhous,Paul H. Schlesinger +6 more
TL;DR: Verapamil and two other calcium channel blockers, as well as vinblastine and daunomycin, each slowed the release and increased the accumulation of chloroquine by resistant (but not susceptible) Plasmodium falciparum.
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Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: Characterization and evidence for receptor recycling
TL;DR: The results, taken together with the observation that cycloheximide has no effect on ligand uptake, suggest that receptors must be spared from degradation and that reutilization of receptors probably occurs.