J
Janine McCaughey
Researcher at University of Bristol
Publications - 13
Citations - 274
Janine McCaughey is an academic researcher from University of Bristol. The author has contributed to research in topics: Endoplasmic reticulum & COPII. The author has an hindex of 6, co-authored 12 publications receiving 191 citations. Previous affiliations of Janine McCaughey include Leibniz University of Hanover.
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Journal ArticleDOI
ER-to-Golgi trafficking of procollagen in the absence of large carriers
TL;DR: Analysis of endogenous procollagen and a new engineered GFP-tagged form shows that transport to the Golgi occurs in the absence of large (>350 nm) carriers, and proposes a short-loop model of COPII-dependent ER-to-Golgi traffic that does not invoke long-range trafficking of large vesicular structures.
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TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion
Janine McCaughey,Victoria J. Miller,Nicola L. Stevenson,Anna K. Brown,Annika Budnik,Kate J. Heesom,Dominic Alibhai,David J. Stephens +7 more
TL;DR: It is shown that TFG organizes transitional ER (tER) and ER exit sites (ERESs) into larger structures and suggests a key relationship between the structure and function of ERESs and a central role for TFG in optimizing COPII assembly for procollagen export.
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COPII-dependent ER export in animal cells: adaptation and control for diverse cargo
TL;DR: The current understanding of COPII is reviewed and the current consensus on its role in packaging diverse cargo proteins is assessed, reported to be over 300 nm.
Journal ArticleDOI
ER-to-Golgi Transport: A Sizeable Problem
TL;DR: Current models describing the dynamics and mechanisms of ER-Golgi transport are discussed, challenging long-held models of vesicular transport of large matrix proteins and are implicating less well-defined carriers and direct interconnections between organelles.
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P4HB recurrent missense mutation causing Cole-Carpenter syndrome.
Meena Balasubramanian,Raja Padidela,Rebecca C. Pollitt,Nick Bishop,M Zulf Mughal,Amaka C. Offiah,Bart E. Wagner,Janine McCaughey,David J. Stephens +8 more
TL;DR: A 3-year old female patient with severe OI who on exome sequencing was found to carry the same missense mutation in P4HB as reported in the original cohort is reported.