K
Kate J. Heesom
Researcher at University of Bristol
Publications - 156
Citations - 6084
Kate J. Heesom is an academic researcher from University of Bristol. The author has contributed to research in topics: Endosome & Retromer. The author has an hindex of 38, co-authored 135 publications receiving 5017 citations. Previous affiliations of Kate J. Heesom include University of Connecticut.
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Journal ArticleDOI
A global analysis of SNX27–retromer assembly and cargo specificity reveals a function in glucose and metal ion transport
Florian Steinberg,Matthew Gallon,Mark O. Winfield,Elaine C. Thomas,Amanda J. Bell,Kate J. Heesom,Jeremy M. Tavaré,Peter J. Cullen +7 more
TL;DR: The data identify the SNX27–retromer as a major endosomal recycling hub required to maintain cellular nutrient homeostasis and establish that direct interaction of theSNX27 PDZ domain with the retromer subunit VPS26 is necessary and sufficient to prevent lysosomal entry of SNX 27 cargo.
Journal ArticleDOI
Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein.
Andrew D. Davidson,Maia Kavanagh Williamson,Sebastian D Lewis,Deborah K. Shoemark,Miles W. Carroll,Kate J. Heesom,Maria Zambon,Joanna Ellis,Philip A. Lewis,Julian A. Hiscox,Julian A. Hiscox,David A. Matthews +11 more
TL;DR: In this paper, the authors used direct RNA sequencing to determine the transcriptome of SARS-CoV-2 grown in Vero E6 cells which is widely used to propagate the novel coronavirus.
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Nanoparticles can cause DNA damage across a cellular barrier
Gevdeep Bhabra,Aman Sood,Brenton Fisher,Laura Cartwright,Margaret Saunders,William Howard Evans,Annmarie Surprenant,Gloria Lopez-Castejon,Stephen Mann,Sean A. Davis,Lauren A. Hails,Eileen Ingham,Paul Verkade,Jon D. Lane,Kate J. Heesom,Roger B. Newson,C. P. Case +16 more
TL;DR: It is shown that cobalt-chromium nanoparticles (29.5 +/- 6.3 nm in diameter) can damage human fibroblast cells across an intact cellular barrier without having to cross the barrier.
Journal ArticleDOI
The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes.
TL;DR: Results demonstrate that serine 454 of ATP-citrate lyase is a novel and majorin vivo substrate for protein kinase B.
Journal ArticleDOI
Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling
Kerrie E. McNally,Rebecca A. Faulkner,Florian Steinberg,Matthew Gallon,Rajesh Ghai,David Pim,Paul F. Langton,Neil D. Pearson,Chris M. Danson,Heike Nägele,Lindsey L. Morris,Amika Singla,Brittany L. Overlee,Kate J. Heesom,Richard B. Sessions,Lawrence Banks,Brett M. Collins,Imre Berger,Daniel D. Billadeau,Ezra Burstein,Peter J. Cullen +20 more
TL;DR: The discovery of an ancient and conserved multiprotein complex that orchestrates cargo retrieval and recycling and, importantly, is biochemically and functionally distinct from the established retromer pathway is described.