M
Mark A. Schroeder
Researcher at Washington University in St. Louis
Publications - 197
Citations - 8216
Mark A. Schroeder is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Transplantation & Internal medicine. The author has an hindex of 43, co-authored 173 publications receiving 6712 citations. Previous affiliations of Mark A. Schroeder include University of Washington & Mayo Clinic.
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Journal ArticleDOI
TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes
John S. Welch,Allegra A. Petti,Christopher A. Miller,Catrina Fronick,Michelle O'Laughlin,Robert S. Fulton,Richard K. Wilson,Jack Baty,Eric J. Duncavage,Bevan Tandon,Yi-Shan Lee,Lukas D. Wartman,Geoffrey L. Uy,Armin Ghobadi,Michael H. Tomasson,Iskra Pusic,Rizwan Romee,Todd A. Fehniger,Keith Stockerl-Goldstein,Ravi Vij,Stephen T. Oh,Camille N. Abboud,Amanda F. Cashen,Mark A. Schroeder,Meagan A. Jacoby,Sharon Heath,Kierstin Luber,Megan Janke,Andrew Hantel,Niloufer Khan,Madina Sukhanova,Randall W. Knoebel,Wendy Stock,Timothy A. Graubert,Matthew J. Walter,Peter Westervelt,Daniel C. Link,John F. DiPersio,Timothy J. Ley +38 more
TL;DR: Patients with AML and MDS who had cytogenetic abnormalities associated with unfavorable risk, TP53 mutations, or both had favorable clinical responses and robust (but incomplete) mutation clearance after receiving serial 10-day courses of decitabine.
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The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.
Kui Ming Chan,Dong Fang,Haiyun Gan,Rintaro Hashizume,Chuanhe Yu,Mark A. Schroeder,Nalin Gupta,Sabine Mueller,C. David James,Robert B. Jenkins,Jann N. Sarkaria,Zhiguo Zhang +11 more
TL;DR: Results indicate that H3.3K27M mutation reprograms epigenetic landscape and gene expression, which may drive tumorigenesis.
Journal ArticleDOI
Stretch induces cytokine release by alveolar epithelial cells in vitro.
TL;DR: It is concluded that deformation per se can trigger inflammatory signaling and that alveolar epithelial cells may be active participants in the alveolitis associated with ventilator-induced lung injury.
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Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme.
Caterina Giannini,Jann N. Sarkaria,Atsushi Saito,Joon H. Uhm,Evanthia Galanis,Brett L. Carlson,Mark A. Schroeder,C. David James +7 more
TL;DR: Because the heterotopic-to-orthotopic transfer and propagation of glioblastoma multiforme preserves the receptor tyrosine kinase (RTK) gene amplification of patient tumors, this approach should facilitate investigations for determining the extent to which RTK amplification status influences tumor response to RTK-directed therapies.
Journal ArticleDOI
Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts
Gaspar J. Kitange,Brett L. Carlson,Mark A. Schroeder,Patrick T. Grogan,Jeff D. Lamont,Paul A. Decker,Wenting Wu,C. David James,Jann N. Sarkaria +8 more
TL;DR: MGMT expression is dynamically regulated in some MGMT nonmethylated tumors, and in these tumors, protracted dosing regimens may not be effective.