Janneke Wilschut

TL;DR: Two independent microsimulation modeling groups from the Cancer Intervention and Surveillance Modeling Network (CISNET), funded by the National Cancer Institute, used a comparative modeling approach to compare life-years gained relative to resource use of different strategies for colorectal cancer screening.

TL;DR: In conclusion, immunochemical faecal occult blood testing is considerably more effective than gFOBT screening within the range of tested cut-off values and an acceptable trade-off between detection rate and NNscope.

TL;DR: FIT screening is more cost-effective at a cutoff level of 50 ng/mL than at higher cutoff levels, which is considerably lower than the values used in current practice.

TL;DR: There is no difference in attendance for subjects offered 1- or 2-sample FIT screening, which allows for the development of efficient FIT Screening strategies that can be adapted for local colonoscopy capacities, rather than varying the cut-off value in a 1-sample strategy.

TL;DR: The improvements in costs and effects of individualizing CRC screening on a population level were only marginal, and individualized guidelines could contribute to decreasing disparities between blacks and whites.