J
Jason C. Huang
Researcher at National Yang-Ming University
Publications - 29
Citations - 1088
Jason C. Huang is an academic researcher from National Yang-Ming University. The author has contributed to research in topics: Influenza A virus & Hemagglutinin (influenza). The author has an hindex of 13, co-authored 26 publications receiving 892 citations.
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Journal ArticleDOI
Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins
Sheng-Fan Wang,Sheng-Fan Wang,Sung-Pin Tseng,Chia-Hung Yen,Jyh Yuan Yang,Ching Han Tsao,Chun Wei Shen,Kuan Hsuan Chen,Fu-Tong Liu,Wu Tse Liu,Yi Ming Arthur Chen,Jason C. Huang +11 more
TL;DR: Quantitative-PCR and immunofluorescence staining results indicate that SARS-CoV is capable of replication in HL-CZ cells, and of displaying virus-induced cytopathic effects and increased levels of TNF-α, IL-4 and IL-6 two days post-infection, while data from infectivity assays indicate that antibodies against SARsCoV spike proteins may trigger ADE effects.
Journal ArticleDOI
Detection of severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein in human serum using a localized surface plasmon coupled fluorescence fiber-optic biosensor
Jason C. Huang,Ying Feng Chang,Kuan Hsuan Chen,Li Chen Su,Chun Wei Lee,Chii Chang Chen,Yi Ming Arthur Chen,Chien Chou,Chien Chou,Chien Chou +9 more
TL;DR: The LSPCF fiber-optic biosensor shows an ability to detect very low concentration (∼1pg/mL) of SARS-CoV N protein in serum, which should help with the early diagnosis of Sars infection.
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Human-leukocyte antigen class I Cw 1502 and class II DR 0301 genotypes are associated with resistance to severe acute respiratory syndrome (SARS) infection.
Sheng-Fan Wang,Sheng-Fan Wang,Kuan Hsuan Chen,Marcelo Chen,Wen Yi Li,Yen Ju Chen,Ching Han Tsao,Muh Yong Yen,Jason C. Huang,Yi Ming Arthur Chen +9 more
TL;DR: A case-control study of the association of HLA with SARS revealed that the HLA-Cw1502 and DR0301 alleles conferred resistance against SARS infection (p<0.05).
Journal ArticleDOI
DC-SIGN mediates avian H5N1 influenza virus infection in cis and in trans
Sheng-Fan Wang,Jason C. Huang,Yuan Ming Lee,Shih Jen Liu,Yu Jiun Chan,Yat Pang Chau,Pele Chong,Yi Ming Arthur Chen +7 more
TL;DR: DC-SIGN acts as a capture or attachment molecule for avian H5N1 virus, and DC-SIGN mediates infections in cis and in trans.
Journal ArticleDOI
Detection of swine-origin influenza A (H1N1) viruses using a localized surface plasmon coupled fluorescence fiber-optic biosensor.
Ying Feng Chang,Sheng-Fan Wang,Jason C. Huang,Li Chen Su,Li Chen Su,Ling Yao,Ying Chang Li,Ying Chang Li,Suh-Chin Wu,Yi Ming Arthur Chen,Jo Ping Hsieh,Jo Ping Hsieh,Chien Chou,Chien Chou,Chien Chou +14 more
TL;DR: The findings of this study indicate that the high detection sensitivity and specificity of the LSPCF-FOB make it a potentially effective diagnostic tool for clinical S-OIV infection and this technique has the potential to be applied to the development of other clinical microbe detection platforms.