J
Jason Chiang
Researcher at St. Jude Children's Research Hospital
Publications - 49
Citations - 751
Jason Chiang is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 11, co-authored 32 publications receiving 397 citations. Previous affiliations of Jason Chiang include University of Pittsburgh.
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Journal ArticleDOI
Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features.
Maximilian Y. Deng,Martin Sill,Jason Chiang,Jens Schittenhelm,Martin Ebinger,Martin U. Schuhmann,Camelia M. Monoranu,Till Milde,Andrea Wittmann,Christian Hartmann,Clemens Sommer,Werner Paulus,Jutta Gärtner,Wolfgang Brück,Thomas Rüdiger,Alfred Leipold,Zane Jaunmuktane,Zane Jaunmuktane,Sebastian Brandner,Sebastian Brandner,Felice Giangaspero,Paolo Nozza,Jaume Mora,Andres Morales La Madrid,Ofelia Cruz Martinez,Jordan R. Hansford,Torsten Pietsch,Anna Tietze,Pablo Hernáiz-Driever,Iris Stoler,David Capper,Andrey Korshunov,Andrey Korshunov,David W. Ellison,Andreas von Deimling,Andreas von Deimling,Stefan M. Pfister,Stefan M. Pfister,Felix Sahm,Felix Sahm,David T.W. Jones +40 more
TL;DR: This study proposes an additional molecular layer to the current histopathological classification of DLGNT, of particular use for cases without typical morphological or radiological characteristics, such as diffuse growth and radiologic leptomeningeal dissemination.
Journal ArticleDOI
Inflammatory Reaction in Neurological Diseases
TL;DR: Findings suggest that patients with and without ARD were found to have similar risks of developing dementia and the Longitudinal Health Insurance Database 2000 to investigate and compare the risk of dementia between patients clinically diagnosed with autoimmune rheumatic diseases and non-ARD patients during a 5-year follow-up period.
Journal ArticleDOI
Structure and evolution of double minutes in diagnosis and relapse brain tumors
Ke Xu,Liang Ding,Ti-Cheng Chang,Ying Shao,Jason Chiang,Heather L. Mulder,Shuoguo Wang,Timothy I. Shaw,Ji Wen,Laura D. Hover,Clay McLeod,Yong-Dong Wang,John Easton,Michael Rusch,James Dalton,James R. Downing,David W. Ellison,Jinghui Zhang,Suzanne J. Baker,Gang Wu +19 more
TL;DR: The results suggest that double minutes readily evolve, increasing tumor heterogeneity rapidly, and understanding patterns of double minute evolution can shed light on future therapeutic solutions to brain tumors carrying such variants.
Journal ArticleDOI
Molecular pathology of paediatric central nervous system tumours.
Jason Chiang,David W. Ellison +1 more
TL;DR: Molecular genetic alterations in paediatric CNS tumours, including those in low‐grade and high‐grade gliomas, ependymomas, and embryonal tumours are reviewed.
Journal ArticleDOI
Cell-surface antigen profiling of pediatric brain tumors: B7-H3 is consistently expressed and can be targeted via local or systemic CAR T-cell delivery.
Dalia Haydar,Haley Houke,Jason Chiang,Zhongzhen Yi,Zelda Odé,Kenneth J. Caldwell,Xiaoyan Zhu,Kimberly S Mercer,Jennifer L. Stripay,Timothy I. Shaw,Peter Vogel,Christopher DeRenzo,Suzanne J. Baker,Martine F. Roussel,Stephen Gottschalk,Giedre Krenciute +15 more
TL;DR: The importance of studying target antigen and HLA class-I expression in PDOX samples for the future design of immunotherapies is highlighted, and active preclinical and clinical exploration of B7-H3-targeted CAR T-cell therapies for a broad spectrum of pediatric brain tumors are supported.