M
Martin U. Schuhmann
Researcher at University of Tübingen
Publications - 201
Citations - 11266
Martin U. Schuhmann is an academic researcher from University of Tübingen. The author has contributed to research in topics: Medicine & Intracranial pressure. The author has an hindex of 29, co-authored 174 publications receiving 9038 citations. Previous affiliations of Martin U. Schuhmann include Leipzig University & University of Hamburg.
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Journal ArticleDOI
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
Jeremy Schwartzentruber,Andrey Korshunov,Xiaoyang Liu,David T.W. Jones,Elke Pfaff,Karine Jacob,Dominik Sturm,Adam M. Fontebasso,Dong Anh Khuong Quang,Martje Tönjes,Volker Hovestadt,Steffen Albrecht,Marcel Kool,André Nantel,Carolin Konermann,Anders Lindroth,Natalie Jäger,Tobias Rausch,Marina Ryzhova,Jan O. Korbel,Thomas Hielscher,Peter Hauser,Miklós Garami,Almos Klekner,László Bognár,Martin Ebinger,Martin U. Schuhmann,Wolfram Scheurlen,Arnulf Pekrun,Michael C. Frühwald,Wolfgang Roggendorf,CM Kramm,Matthias Dürken,Jeffrey Atkinson,Pierre Lepage,Alexandre Montpetit,Magdalena Zakrzewska,Krzystof Zakrzewski,Pawel P. Liberski,Zhifeng Dong,Peter M. Siegel,Andreas E. Kulozik,Marc Zapatka,Abhijit Guha,David Malkin,Jörg Felsberg,Guido Reifenberger,Andreas von Deimling,Andreas von Deimling,Koichi Ichimura,V. Peter Collins,Hendrik Witt,Hendrik Witt,Till Milde,Till Milde,Olaf Witt,Olaf Witt,Cindy Zhang,Pedro Castelo-Branco,Peter Lichter,Damien Faury,Uri Tabori,Christoph Plass,Jacek Majewski,Stefan M. Pfister,Stefan M. Pfister,Nada Jabado +66 more
TL;DR: The presence of H3F3A/ATRX-DAXX/TP53 mutations was strongly associated with alternative lengthening of telomeres and specific gene expression profiles, suggesting that defects of the chromatin architecture underlie paediatric and young adult GBM pathogenesis.
Journal ArticleDOI
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.
Dominik Sturm,Hendrik Witt,Hendrik Witt,Volker Hovestadt,Dong Anh Khuong-Quang,David T.W. Jones,Carolin Konermann,Elke Pfaff,Martje Tönjes,Martin Sill,Sebastian Bender,Marcel Kool,Marc Zapatka,Natalia Becker,Manuela Zucknick,Thomas Hielscher,Xiaoyang Liu,Adam M. Fontebasso,Marina Ryzhova,Steffen Albrecht,Karine Jacob,Marietta Wolter,Martin Ebinger,Martin U. Schuhmann,Timothy E. Van Meter,Michael C. Frühwald,Holger Hauch,Arnulf Pekrun,Bernhard Radlwimmer,Tim Niehues,Gregor Von Komorowski,Matthias Dürken,Andreas E. Kulozik,Jenny Madden,Andrew M. Donson,Nicholas K. Foreman,Rachid Drissi,Maryam Fouladi,Wolfram Scheurlen,Andreas von Deimling,Andreas von Deimling,Camelia M. Monoranu,Wolfgang Roggendorf,Christel Herold-Mende,Andreas Unterberg,Christof M. Kramm,Jörg Felsberg,Christian Hartmann,Benedikt Wiestler,Wolfgang Wick,Till Milde,Till Milde,Olaf Witt,Olaf Witt,Anders Lindroth,Jeremy Schwartzentruber,Damien Faury,Adam Fleming,Magdalena Zakrzewska,Pawel P. Liberski,Krzysztof Zakrzewski,Peter Hauser,Miklós Garami,Almos Klekner,László Bognár,Sorana Morrissy,Florence M.G. Cavalli,Michael D. Taylor,Peter van Sluis,Jan Koster,Rogier Versteeg,Richard Volckmann,Tom Mikkelsen,Kenneth Aldape,Guido Reifenberger,V. Peter Collins,Jacek Majewski,Andrey Korshunov,Peter Lichter,Christoph Plass,Nada Jabado,Stefan M. Pfister,Stefan M. Pfister +82 more
TL;DR: It is demonstrated that each H3F3A mutation defines an epigenetic subgroup of GBM with a distinct global methylation pattern, and that they are mutually exclusive with IDH1 mutations, which characterize a third mutation-defined subgroup.
Journal ArticleDOI
Dissecting the genomic complexity underlying medulloblastoma
David T.W. Jones,Natalie Jäger,Marcel Kool,Thomas Zichner,Barbara Hutter,Marc Sultan,Yoon Jae Cho,Trevor J. Pugh,Volker Hovestadt,Adrian M. Stütz,Tobias Rausch,Hans-Jörg Warnatz,Marina Ryzhova,Sebastian Bender,Dominik Sturm,Sabrina Pleier,Huriye Cin,Elke Pfaff,Laura Sieber,Andrea Wittmann,Marc Remke,Hendrik Witt,Hendrik Witt,Sonja Hutter,Theophilos Tzaridis,Joachim Weischenfeldt,Benjamin Raeder,Meryem Avci,Vyacheslav Amstislavskiy,Marc Zapatka,Ursula D. Weber,Qi Wang,Bärbel Lasitschka,Cynthia C. Bartholomae,Manfred Schmidt,Christof von Kalle,Volker Ast,Chris Lawerenz,Jürgen Eils,Rolf Kabbe,Vladimir Benes,Peter van Sluis,Jan Koster,Richard Volckmann,David Shih,Matthew J. Betts,Robert B. Russell,Simona Coco,Gian Paolo Tonini,Ulrich Schüller,Volkmar Hans,Norbert Graf,Yoo-Jin Kim,Camelia M. Monoranu,Wolfgang Roggendorf,Andreas Unterberg,Christel Herold-Mende,Till Milde,Till Milde,Andreas E. Kulozik,Andreas von Deimling,Andreas von Deimling,Olaf Witt,Olaf Witt,Eberhard Maass,Jochen Rössler,Martin Ebinger,Martin U. Schuhmann,Michael C. Frühwald,Martin Hasselblatt,Nada Jabado,Stefan Rutkowski,André O. von Bueren,Daniel Williamson,Steven C. Clifford,Martin G. McCabe,Martin G. McCabe,V. Peter Collins,Stephan Wolf,Stefan Wiemann,Hans Lehrach,Benedikt Brors,Wolfram Scheurlen,Jörg Felsberg,Guido Reifenberger,Paul A. Northcott,Michael D. Taylor,Matthew Meyerson,Matthew Meyerson,Scott L. Pomeroy,Scott L. Pomeroy,Marie-Laure Yaspo,Jan O. Korbel,Andrey Korshunov,Andrey Korshunov,Roland Eils,Roland Eils,Stefan M. Pfister,Stefan M. Pfister,Peter Lichter +99 more
TL;DR: An integrative deep-sequencing analysis of 125 tumour–normal pairs enhances the understanding of the genomic complexity and heterogeneity underlying medulloblastoma, and provides several potential targets for new therapeutics, especially for Group 3 and 4 patients.
Journal ArticleDOI
The whole-genome landscape of medulloblastoma subtypes
Paul A. Northcott,Paul A. Northcott,Ivo Buchhalter,Ivo Buchhalter,A. Sorana Morrissy,Volker Hovestadt,Joachim Weischenfeldt,Tobias Ehrenberger,Susanne Gröbner,Maia Segura-Wang,Thomas Zichner,Vasilisa A. Rudneva,Hans-Jörg Warnatz,Nikos Sidiropoulos,Aaron H. Phillips,Steven E. Schumacher,Kortine Kleinheinz,Sebastian M. Waszak,Serap Erkek,Serap Erkek,David T.W. Jones,Barbara C. Worst,Marcel Kool,Marc Zapatka,Natalie Jäger,Lukas Chavez,Barbara Hutter,Matthias Bieg,Nagarajan Paramasivam,Nagarajan Paramasivam,Michael Heinold,Michael Heinold,Zuguang Gu,Naveed Ishaque,Christina Jäger-Schmidt,Charles D. Imbusch,Alke Jugold,Daniel Hübschmann,Daniel Hübschmann,Daniel Hübschmann,Thomas Risch,Vyacheslav Amstislavskiy,Francisco German Rodriguez Gonzalez,Ursula D. Weber,Stephan Wolf,Giles W. Robinson,Xin Zhou,Gang Wu,David Finkelstein,Yanling Liu,Florence M.G. Cavalli,Betty Luu,Vijay Ramaswamy,Xiaochong Wu,Jan Koster,Marina Ryzhova,Yoon Jae Cho,Scott L. Pomeroy,Christel Herold-Mende,Martin U. Schuhmann,Martin Ebinger,Linda M. Liau,Jaume Mora,Roger E. McLendon,Nada Jabado,Toshihiro Kumabe,Eric Chuah,Yussanne Ma,Richard A. Moore,Andrew J. Mungall,Karen Mungall,Nina Thiessen,Kane Tse,Tina Wong,Steven J.M. Jones,Olaf Witt,Till Milde,Andreas von Deimling,David Capper,Andrey Korshunov,Marie-Laure Yaspo,Richard W. Kriwacki,Amar Gajjar,Jinghui Zhang,Rameen Beroukhim,Ernest Fraenkel,Jan O. Korbel,Benedikt Brors,Matthias Schlesner,Roland Eils,Roland Eils,Marco A. Marra,Stefan M. Pfister,Stefan M. Pfister,Michael D. Taylor,Peter Lichter +95 more
TL;DR: The application of integrative genomics to an extensive cohort of clinical samples derived from a single childhood cancer entity revealed a series of cancer genes and biologically relevant subtype diversity that represent attractive therapeutic targets for the treatment of patients with medulloblastoma.
Journal ArticleDOI
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
David T.W. Jones,Barbara Hutter,Natalie Jäger,Andrey Korshunov,Andrey Korshunov,Marcel Kool,Hans-Jörg Warnatz,Thomas Zichner,Sally R. Lambert,Marina Ryzhova,Dong Anh Khuong Quang,Adam M. Fontebasso,Adrian M. Stütz,Sonja Hutter,Marc Zuckermann,Dominik Sturm,Jan Gronych,Bärbel Lasitschka,Sabine Schmidt,Huriye Seker-Cin,Hendrik Witt,Hendrik Witt,Marc Sultan,Meryem Ralser,Paul A. Northcott,Volker Hovestadt,Sebastian Bender,Elke Pfaff,Sebastian Stark,Damien Faury,Jeremy Schwartzentruber,Jacek Majewski,Ursula D. Weber,Marc Zapatka,Benjamin Raeder,Matthias Schlesner,Catherine L. Worth,Cynthia C. Bartholomae,Christof von Kalle,Charles D. Imbusch,S. Radomski,S. Radomski,Chris Lawerenz,Peter van Sluis,Jan Koster,Richard Volckmann,Rogier Versteeg,Hans Lehrach,Camelia M. Monoranu,Beate Winkler,Andreas Unterberg,Christel Herold-Mende,Till Milde,Till Milde,Andreas E. Kulozik,Martin Ebinger,Martin U. Schuhmann,Yoon Jae Cho,Scott L. Pomeroy,Scott L. Pomeroy,Andreas von Deimling,Andreas von Deimling,Olaf Witt,Olaf Witt,Michael D. Taylor,Stephan Wolf,Matthias A. Karajannis,Charles G. Eberhart,Wolfram Scheurlen,Martin Hasselblatt,Keith L. Ligon,Mark W. Kieran,Jan O. Korbel,Marie-Laure Yaspo,Benedikt Brors,Jörg Felsberg,Guido Reifenberger,V. Peter Collins,Nada Jabado,Nada Jabado,Roland Eils,Roland Eils,Peter Lichter +82 more
TL;DR: Recurrent activating mutations in FGFR1 and PTPN11 and new NTRK2 fusion genes in non-cerebellar tumors and new BRAF-activating changes were observed, indicating that pilocytic astrocytoma is predominantly a single-pathway disease.