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Xiaoyan Zhu
Researcher at St. Jude Children's Research Hospital
Publications - 27
Citations - 3626
Xiaoyan Zhu is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: PTEN & Glioma. The author has an hindex of 14, co-authored 25 publications receiving 3135 citations. Previous affiliations of Xiaoyan Zhu include University of Tennessee Health Science Center.
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Journal ArticleDOI
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
Gang Wu,Alexander K. Diaz,Alexander K. Diaz,Barbara S. Paugh,Sherri Rankin,Bensheng Ju,Yongjin Li,Xiaoyan Zhu,Chunxu Qu,Xiang Chen,Junyuan Zhang,John Easton,Michael N. Edmonson,Xiaotu Ma,Charles Lu,Panduka Nagahawatte,Erin Hedlund,Michael Rusch,Stanley Pounds,Tong Lin,Arzu Onar-Thomas,Robert Huether,Richard W. Kriwacki,Matthew Parker,Pankaj Gupta,Jared Becksfort,Lei Wei,Heather L. Mulder,Kristy Boggs,Bhavin Vadodaria,Donald Yergeau,Jake C. Russell,Kerri Ochoa,Robert S. Fulton,Lucinda Fulton,Chris Jones,Frederick A. Boop,Alberto Broniscer,Cynthia Wetmore,Amar Gajjar,Li Ding,Elaine R. Mardis,Richard K. Wilson,Michael R. Taylor,James R. Downing,David W. Ellison,Jinghui Zhang,Suzanne J. Baker,Suzanne J. Baker +48 more
TL;DR: In this article, the authors analyzed 127 pediatric HGGs, including diffuse intrinsic pontine gliomas (DIPGs) and non-brainstem HGG (NBS-HGGs), by whole-genome, whole-exome and/or transcriptome sequencing.
Journal ArticleDOI
Novel mutations target distinct subgroups of medulloblastoma
Giles W. Robinson,Matthew Parker,Tanya A. Kranenburg,Charles Lu,Charles Lu,Xiang Chen,Li Ding,Li Ding,Timothy N. Phoenix,Erin Hedlund,Lei Wei,Xiaoyan Zhu,Nader Chalhoub,Suzanne J. Baker,Robert Huether,Richard W. Kriwacki,Natasha Curley,Radhika Thiruvenkatam,Jianmin Wang,Gang Wu,Michael Rusch,Xin Hong,Xin Hong,Jared Becksfort,Pankaj Gupta,Jing Ma,John Easton,Bhavin Vadodaria,Arzu Onar-Thomas,Tong Lin,Shaoyi Li,Stanley Pounds,Steven W. Paugh,David Zhao,Daisuke Kawauchi,Martine F. Roussel,David Finkelstein,David W. Ellison,Ching C. Lau,Eric Bouffet,Tim Hassall,Tim Hassall,Sridharan Gururangan,Sridharan Gururangan,Richard J. Cohn,Richard J. Cohn,Robert S. Fulton,Robert S. Fulton,Lucinda L. Fulton,Lucinda L. Fulton,David J. Dooling,David J. Dooling,Kerri Ochoa,Kerri Ochoa,Amar Gajjar,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Jinghui Zhang,Richard J. Gilbertson +59 more
TL;DR: Modelling of mutations in mouse lower rhombic lip progenitors that generate WNT-subgroup tumours identified genes that maintain this cell lineage (DDX3X), as well as mutated genes that initiate (CDH1) or cooperate (PIK3CA) in tumorigenesis.
Journal ArticleDOI
Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease
Chang-Hyuk Kwon,Xiaoyan Zhu,Junyuan Zhang,Lori L. Knoop,Ruby Tharp,Richard J. Smeyne,Charles G. Eberhart,Peter C. Burger,Suzanne J. Baker,Suzanne J. Baker +9 more
TL;DR: Results indicate that Pten regulates neuronal size in vivo in a cell-autonomous manner and provide new insights into the etiology of Lhermitte-Duclos disease.
Journal ArticleDOI
Cooperativity within and among Pten, p53, and Rb Pathways Induces High-Grade Astrocytoma in Adult Brain
Lionel M.L. Chow,Raelene Endersby,Xiaoyan Zhu,Sherri Rankin,Chunxu Qu,Junyuan Zhang,Alberto Broniscer,David W. Ellison,Suzanne J. Baker +8 more
TL;DR: Gene expression profiling revealed striking similarities to subclasses of human diffuse astrocytoma and selection for mutation of multiple genes within a pathway was shown by somatic amplifications of genes in the PI3K or Rb pathway in tumors in which Pten or R b deletion was an initiating event.
Journal ArticleDOI
mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo.
TL;DR: In this paper, the tumor suppressor Pten is required for correct maintenance of mammalian neuronal soma size, and the contribution of mTor signaling to Pten-mediated growth regulation in the mammalian nervous system was determined.