Jason Chiang

TL;DR: This study proposes an additional molecular layer to the current histopathological classification of DLGNT, of particular use for cases without typical morphological or radiological characteristics, such as diffuse growth and radiologic leptomeningeal dissemination.

TL;DR: Findings suggest that patients with and without ARD were found to have similar risks of developing dementia and the Longitudinal Health Insurance Database 2000 to investigate and compare the risk of dementia between patients clinically diagnosed with autoimmune rheumatic diseases and non-ARD patients during a 5-year follow-up period.

TL;DR: The results suggest that double minutes readily evolve, increasing tumor heterogeneity rapidly, and understanding patterns of double minute evolution can shed light on future therapeutic solutions to brain tumors carrying such variants.

TL;DR: Molecular genetic alterations in paediatric CNS tumours, including those in low‐grade and high‐grade gliomas, ependymomas, and embryonal tumours are reviewed.

TL;DR: The importance of studying target antigen and HLA class-I expression in PDOX samples for the future design of immunotherapies is highlighted, and active preclinical and clinical exploration of B7-H3-targeted CAR T-cell therapies for a broad spectrum of pediatric brain tumors are supported.