J
Jason N. Berman
Researcher at University of Ottawa
Publications - 115
Citations - 3272
Jason N. Berman is an academic researcher from University of Ottawa. The author has contributed to research in topics: Zebrafish & Cancer. The author has an hindex of 30, co-authored 97 publications receiving 2676 citations. Previous affiliations of Jason N. Berman include Boston Children's Hospital & Children's Oncology Group.
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Journal ArticleDOI
Zebrafish xenografts as a tool for in vivo studies on human cancer
Martina Konantz,Tugce B. Balci,Udo F. Hartwig,Graham Dellaire,Maya C. André,Maya C. André,Jason N. Berman,Claudia Lengerke +7 more
TL;DR: Current data on xenotransplantation of human cells into zebrafish is summarized, highlighting the advantages and limitations of this model in comparison to classical murine models of xenotranplantation.
Journal ArticleDOI
Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis
Amal El-Naggar,Chansey J. Veinotte,Hongwei Cheng,Thomas G. P. Grunewald,Gian Luca Negri,Syam Prakash Somasekharan,Dale Corkery,Franck Tirode,Joan Mathers,Debjit Khan,Alastair H. Kyle,Jennifer H.E. Baker,Nancy E. LePard,Steven McKinney,Shamil Hajee,Momir Bosiljcic,Gabriel Leprivier,Cristina E. Tognon,Andrew I. Minchinton,Kevin L. Bennewith,Olivier Delattre,Yuzhuo Wang,Graham Dellaire,Jason N. Berman,Jason N. Berman,Poul H. Sorensen +25 more
TL;DR: The data establish YB-1 as a critical regulator of hypoxia-inducible factor 1α (HIF1α) expression in sarcoma cells and enhances HIF1 α protein expression by directly binding to and activating translation of Hif1A messages, which leads to H IF1α-mediated sarcomas cell invasion and enhanced metastatic capacity in vivo.
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CRISPR multitargeter: a web tool to find common and unique CRISPR single guide RNA targets in a set of similar sequences.
TL;DR: The design of unique targets in alternative exons is helpful because it will facilitate functional genomic studies of transcript isoforms and its application to duplicated genes may simplify multi-gene mutational targeting experiments, and this program provides a unique interface that will enhance use of CRISPR/Cas technology.
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The pu.1 promoter drives myeloid gene expression in zebrafish
Karl Hsu,David Traver,Jeffery L. Kutok,Andreas Hagen,Ting Xi Liu,Barry H. Paw,Jennifer Rhodes,Jason N. Berman,Leonard I. Zon,John P. Kanki,A. Thomas Look +10 more
TL;DR: The zebrafish zpu.1 promoter fragment used here is capable of driving reporter gene expression in subsets of embryonic and adult hematopoietic cells, and these transgenic lines will be useful to dissect the cellular and molecular control of myeloid cell differentiation.
Journal ArticleDOI
Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era.
TL;DR: The use of zebrafish embryos in drug screening and the potential for xenotransplantation approaches to be adopted as a preclinical tool to identify and prioritize therapies for further clinical evaluation are highlighted.