S
Steven McKinney
Researcher at BC Cancer Agency
Publications - 37
Citations - 9398
Steven McKinney is an academic researcher from BC Cancer Agency. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 24, co-authored 35 publications receiving 8033 citations. Previous affiliations of Steven McKinney include University of British Columbia & Vancouver General Hospital.
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Journal ArticleDOI
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Christina Curtis,Christina Curtis,Sohrab P. Shah,Suet-Feung Chin,Gulisa Turashvili,Oscar M. Rueda,Mark J Dunning,Doug Speed,Doug Speed,Andy G. Lynch,Shamith A. Samarajiwa,Yinyin Yuan,Stefan Gräf,Gavin Ha,Gholamreza Haffari,Ali Bashashati,Roslin Russell,Steven McKinney,Anita Langerød,Andrew R. Green,Elena Provenzano,Gordon C. Wishart,Sarah E Pinder,Peter H. Watson,Peter H. Watson,Florian Markowetz,Leigh C. Murphy,Ian O. Ellis,Arnie Purushotham,Arnie Purushotham,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,James D. Brenton,Simon Tavaré,Carlos Caldas,Samuel Aparicio +35 more
TL;DR: The results provide a novel molecular stratification of the breast cancer population, derived from the impact of somatic CNAs on the transcriptome, and identify novel subgroups with distinct clinical outcomes, which reproduced in the validation cohort.
Journal ArticleDOI
Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype.
Maggie C.U. Cheang,David Voduc,Chris Bajdik,Samuel Leung,Steven McKinney,Stephen Chia,Charles M. Perou,Torsten O. Nielsen +7 more
TL;DR: The expanded surrogate immunopanel of estrogen receptor, progesterone receptor, human HER-2, EGFR, and cytokeratin 5/6 provides a more specific definition of basal-like breast cancer that better predicts breast cancer survival.
Journal ArticleDOI
Ovarian Carcinoma Subtypes Are Different Diseases: Implications for Biomarker Studies
Martin Köbel,Martin Köbel,Steve E. Kalloger,Niki Boyd,Steven McKinney,Erika Mehl,Chana Palmer,Samuel Leung,Nathan J. Bowen,Diana N. Ionescu,Ashish Rajput,Leah M Prentice,Dianne Miller,Jennifer L. Santos,Kenneth D. Swenerton,C. Blake Gilks,David G. Huntsman +16 more
TL;DR: The association of biomarker expression with survival varies substantially between subtypes, and can easily be overlooked in whole cohort analyses.
Journal ArticleDOI
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.
Hong Xu,Marco Di Antonio,Steven McKinney,Veena Mathew,Brandon Ho,Nigel J. O'Neil,Nancy Dos Santos,Jennifer Silvester,Vivien Wei,Jessica Garcia,Farhia Kabeer,Daniel Lai,Priscilla Soriano,Judit P. Banáth,Derek S. Chiu,Damian Yap,Daniel D. Le,Frank B Ye,Anni Zhang,Kelsie L. Thu,John Soong,Shu chuan Lin,Angela Hsin Chin Tsai,Tomo Osako,Teresa Ruiz de Algara,Darren N. Saunders,Jason Wong,Jian Xian,Marcel B. Bally,James D. Brenton,Grant W. Brown,Sohrab P. Shah,David W. Cescon,David W. Cescon,Tak W. Mak,Carlos Caldas,Peter C. Stirling,Phil Hieter,Shankar Balasubramanian,Samuel Aparicio +39 more
TL;DR: CX-5461 is a G-quadruplex stabilizer, with specific toxicity against BRCA deficiencies in cancer cells and polyclonal patient-derived xenograft models, including tumours resistant to PARP inhibition.
Journal ArticleDOI
Transcriptome analysis of the normal human mammary cell commitment and differentiation process.
Afshin Raouf,Yun Zhao,Karen To,John Stingl,Allen Delaney,Mary Barbara,Norman N. Iscove,Steven J.M. Jones,Steven McKinney,Joanne T. Emerman,Samuel Aparicio,Marco A. Marra,Marco A. Marra,Connie J. Eaves,Connie J. Eaves +14 more
TL;DR: Functional studies showed NOTCH3 signaling to be critical for this differentiation event to occur in vitro and provide an initial foundation for future delineation of mechanisms that perturb primitive human mammary cell growth and differentiation.