Jason P. Berninger

TL;DR: In this paper, fathead minnows were exposed to diphenhydramine (DPH; disassociation constant) in water for up to 96'h at 3 nominal pH levels: 6.7, 7.7 and 8.7.

TL;DR: In this paper, a comparative toxicity of P.parvum filtrate from a laboratory study (20°C, 12:12 light:dark cycle, f/8 media, 2.4 ǫpsu) to several common standardized in vitro and in vivo models is presented.

TL;DR: A probabilistic model and scoring system were developed and evaluated and it is anticipated that the MaPPFAST database and the associated API prioritization approach will help guide research and/or inform ecological risk assessment.

TL;DR: The utility of read-across approaches to leverage mammalian absorption, distribution, metabolism and elimination data; analyse cross-species molecular target conservation and translate therapeutic MOA to an adverse outcome pathway relevant to aquatic organisms as a means to inform prioritization of drugs for focused toxicity testing and environmental monitoring are demonstrated.

TL;DR: It is demonstrated that mixed-contaminant exposures are ubiquitous and varied in sampled headwater streams and compelling multiple lines of evidence for adverse effects on aquatic communities.