Jason P. Berninger

TL;DR: This chapter critically examine several important aspects of pharmaceuticals, specifically highlighting some of the lessons learned from studying these substances in the environment over the past 15 years and submitting that incorporating such "lessons learned" during environmental risk assessments promises to reduce uncertainties and support more sustainable management efforts.

TL;DR: This work compiled and compared 56 and 150 pairs of acute and subchronic/chronic growth/reproductive toxicity data for fishes and the crustacean Daphnia magna and identified no significant relationships between P. promelas acute median lethal concentrations and growth lowest-observed effect concentrations for class 1 (nonpolar narcosis) chemicals.

TL;DR: Investigating the effects of early life stage exposure to ATR or the model estrogen 17α-ethinylestradiol (EE2) on sexual differentiation and gene expression in gonad tissue confirmed that early development is a sensitive window for estrogenic endocrine disruption in LMB.

TL;DR: The use of pathway-based chemical and biological approaches to assess the risk of chemical mixtures in the Maumee River and a nontargeted mass spectroscopy-based analysis suggested that hepatic endogenous metabolite profiles in caged fish covaried strongly with the occurrence of pesticides and pesticide degradates are described.

TL;DR: The pPLA analysis revealed correlations with signaling, metabolic, and regulatory groups, suggesting that other effects pathways may be associated with chemical contaminants in these waters and indicating the need for broader bioassay coverage to assess potential adverse impacts.