J
Jason Paragas
Researcher at National Institutes of Health
Publications - 50
Citations - 4501
Jason Paragas is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Virus & Ebola virus. The author has an hindex of 28, co-authored 50 publications receiving 4186 citations. Previous affiliations of Jason Paragas include United States Department of the Army & Thomas Jefferson University.
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Journal ArticleDOI
The Ebola virus VP35 protein functions as a type I IFN antagonist.
Christopher F. Basler,Xiuyan Wang,Elke Mühlberger,Victor Volchkov,Jason Paragas,Hans-Dieter Klenk,Adolfo García-Sastre,Peter Palese +7 more
TL;DR: The Ebola virus VP35 protein is likely to inhibit induction of type I IFN in Ebola virus-infected cells and may be an important determinant of Ebola virus virulence in vivo.
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The Ebola Virus VP35 Protein Inhibits Activation of Interferon Regulatory Factor 3
Christopher F. Basler,Andrea Mikulasova,Luis Martinez-Sobrido,Jason Paragas,Elke Mühlberger,Mike Bray,Hans-Dieter Klenk,Peter Palese,Adolfo García-Sastre +8 more
TL;DR: The data suggest that in Ebola virus-infected cells, VP35 inhibits the induction of antiviral genes, including the IFN-β gene, by blocking IRF-3 activation.
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Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys.
Thomas W. Geisbert,Lisa E. Hensley,Peter B. Jahrling,Tom Larsen,Joan B. Geisbert,Jason Paragas,Howard A. Young,Terry M Fredeking,William E. Rote,George P. Vlasuk +9 more
TL;DR: Post-exposure protection with rNAPc2 against Ebola virus in primates provides a new foundation for therapeutic regimens that target the disease process rather than viral replication.
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Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses.
Natalia Frias-Staheli,Nadia V. Giannakopoulos,Marjolein Kikkert,Shannon L. Taylor,Anne Bridgen,Jason Paragas,Juergen A. Richt,Raymond R. R. Rowland,Connie S. Schmaljohn,Deborah J. Lenschow,Eric J. Snijder,Adolfo García-Sastre,Herbert W. Virgin +12 more
TL;DR: The deconjugating activity of viral OTU proteases represents a unique viral strategy to inhibit Ub- and ISG15-dependent antiviral pathways.
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A Proline-Rich Motif within the Matrix Protein of Vesicular Stomatitis Virus and Rabies Virus Interacts with WW Domains of Cellular Proteins: Implications for Viral Budding
TL;DR: A highly conserved, proline-rich motif (PPxY or PY motif) of rhabdoviral M proteins is associated with a possible role in budding mediated by the M protein, and its properties are strikingly analogous to those of the late (L) budding domain identified in the gag-specific protein p2b of Rous sarcoma virus.