J
Jason S. Simon
Researcher at Harvard University
Publications - 12
Citations - 1081
Jason S. Simon is an academic researcher from Harvard University. The author has contributed to research in topics: Genetic linkage & Gene mapping. The author has an hindex of 8, co-authored 12 publications receiving 1072 citations. Previous affiliations of Jason S. Simon include Medical College of Wisconsin.
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Journal ArticleDOI
A genetic linkage map of the laboratory rat, Rattus norvegicus
Howard J. Jacob,Howard J. Jacob,Donna M. Brown,Ruth K. Bunker,Mark J. Daly,Victor J. Dzau,Alec Goodman,George Koike,Vladimir Kren,Theodore W. Kurtz,Åke Lernmark,Göran Levan,Yi pei Mao,Anna Pettersson,Anna Pettersson,Anna Pettersson,Michal Pravenec,Michal Pravenec,Jason S. Simon,Claude Szpirer,Josiane Szpirer,Maria R Trolliet,Eric S. Winer,Eric S. Lander +23 more
TL;DR: The construction of the first complete genetic linkage map of the laboratory rat is reported, identifying 432 markers that show polymorphisms between the SHR and BN rat strains and mapped them in a single SHR × BN F2 intercross.
Journal ArticleDOI
A reference cross DNA panel for zebrafish (Danio rerio) anchored with simple sequence length polymorphisms
Ela W. Knapik,Alec Goodman,O.S. Atkinson,C.T. Roberts,Masahide Shiozawa,C.U. Sim,S. Weksler-Zangen,Maria R Trolliet,C. Futrell,B.A. Innes,George Koike,Michael G. McLaughlin,L. Pierre,Jason S. Simon,E. Vilallonga,M. Roy,P.W. Chiang,Mark C. Fishman,Wolfgang Driever,Howard J. Jacob +19 more
TL;DR: This reference cross DNA will serve as a resource enabling investigators to relate genes or genetic markers directly to a single genetic linkage map and avoid the problem of integrating different maps with different genetic markers, as must be currently done when using randomly amplified polymorphic DNA markers.
Journal ArticleDOI
An integrated genetic linkage map of the laboratory rat
Donna M. Brown,Tara C. Matise,George Koike,Jason S. Simon,Eric S. Winer,Sarah Zangen,Michael G. McLaughlin,Masahide Shiozawa,O. Scott Atkinson,James R. Hudson,Aravinda Chakravarti,Eric S. Lander,Howard J. Jacob +12 more
TL;DR: An integrated map is developed to develop an integrated map, as well as increase the number of markers on the rat genetic map to facilitate more complete whole genome scans in a greater number of strains and provide additional markers in specific genomic regions of interest.
Journal ArticleDOI
Genetic identification of multiple loci that control breast cancer susceptibility in the rat.
Laurie A. Shepel,Hong Lan,Jill D. Haag,Gerlyn M. Brasic,Megan E. Gheen,Jason S. Simon,Peter D. Hoff,Michael A. Newton,Michael N. Gould +8 more
TL;DR: Results show that mammary carcinoma susceptibility in the COP rat is a polygenic trait, and a polymorphism in the human genomic region homologous to the rat Mcs4 region is associated with an increased breast cancer risk in African-American women.
Journal ArticleDOI
Cytosolic phospholipase A2 gene in human and rat: chromosomal localization and polymorphic markers
TL;DR: The chromosomal localization and a simple sequence repeat (SSR) in the cytosolic phospholipase A2 (cPLA2) gene in both human and rat is reported, raising the possibility of coordinate regulation.