Josiane Szpirer

TL;DR: The construction of the first complete genetic linkage map of the laboratory rat is reported, identifying 432 markers that show polymorphisms between the SHR and BN rat strains and mapped them in a single SHR × BN F2 intercross.

TL;DR: It is shown that the brain and behavior of female Afp mutant mice were masculinized and defeminized and that AFP protects the female brain from these effects of estrogens.

TL;DR: It was found that there is a good correlation between the morphological homologies detectable in rat and mouse chromosomes, and homology at the gene level on the other, and argues in favor of the notion that the original gene groups were on separate ancestral chromosomes, which have fused in one rodent species but remained separate in the other and in man.

TL;DR: It is shown that in vitro microperfused collecting ducts of Rhcg-/- acid-loaded mice show reduced apical permeability to NH3 and impaired transepithelial NH3 transport, anticipating a critical role for RhcG in ammonium handling and pH homeostasis both in the kidney and the male reproductive tract.

TL;DR: These studies demonstrate that the HXB and BXH strains can be effectively used for genome scanning studies of complex traits and have revealed several chromosome regions that may be involved in the genetic control of blood pressure and cardiac mass in the rat.