J
Jason Waithman
Researcher at University of Western Australia
Publications - 55
Citations - 4998
Jason Waithman is an academic researcher from University of Western Australia. The author has contributed to research in topics: CD8 & Cytotoxic T cell. The author has an hindex of 25, co-authored 51 publications receiving 4409 citations. Previous affiliations of Jason Waithman include Ludwig Institute for Cancer Research & Walter and Eliza Hall Institute of Medical Research.
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Journal ArticleDOI
Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming.
Rhys S. Allan,Jason Waithman,Sammy Bedoui,Claerwen M. Jones,Jose A Villadangos,Yifan Zhan,Andrew M. Lew,Ken Shortman,William R. Heath,Francis R. Carbone +9 more
TL;DR: After skin infection with herpes simplex virus, cytotoxic T lymphocyte activation required MHC class I-restricted presentation by nonmigratory CD8(+) DCs rather than skin-derived DCs, which supports the argument for initial transport of antigen by migratingDCs, followed by its transfer to the lymphoid-resident DCs for presentation and CTL priming.
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Cross-presentation of viral and self antigens by skin-derived CD103 + dendritic cells
Sammy Bedoui,Paul G. Whitney,Jason Waithman,Jason Waithman,Liv Eidsmo,Linda M. Wakim,Irina Caminschi,Rhys S. Allan,Magdalena Wojtasiak,Ken Shortman,Francis R. Carbone,Andrew G. Brooks,William R. Heath,William R. Heath +13 more
TL;DR: It is shown that CD103+ DCs were the migratory subset most efficient at processing viral antigens into the major histocompatibility complex class I pathway, potentially through cross-presentation.
Journal ArticleDOI
The Dendritic Cell Populations of Mouse Lymph Nodes
Sandrine Henri,David Vremec,Arun T. Kamath,Jason Waithman,Stuart Williams,Christophe Benoist,Kim Burnham,Sem Saeland,Emanuela Handman,Ken Shortman +9 more
TL;DR: The putative LC-derived DC among skin emigrants and in LN also showed strong intracellular staining of langerin, and was identified as the mature form of epidermal Langerhans cells (LC).
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Dendritic cell-induced memory T cell activation in nonlymphoid tissues.
Linda M. Wakim,Jason Waithman,Jason Waithman,Jason Waithman,Nico van Rooijen,Nico van Rooijen,Nico van Rooijen,William R. Heath,William R. Heath,William R. Heath,Francis R. Carbone,Francis R. Carbone,Francis R. Carbone +12 more
TL;DR: Results revealed that memory CD8+ T cell responses can be initiated within peripheral tissues through a tripartite interaction that includes CD4+ T cells and recruited dendritic cells, lending evidence for the existence of a sophisticated T cell response mechanism in extra-lymphoid tissues that can act to control localized infection.
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Cognate CD4+ T cell licensing of dendritic cells in CD8+ T cell immunity
Christopher M. Smith,Nicholas S. Wilson,Jason Waithman,Jose A Villadangos,Francis R. Carbone,William R. Heath,Gabrielle T. Belz +6 more
TL;DR: It is shown here that help is essential for the generation of CTL immunity to herpes simplex virus 1 and that CD4+ T cells mediate help in a cognate, antigen-specific way and that C TL immunity may be heavily dependent on cognate DC licensing.