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Irina Caminschi
Researcher at Monash University, Clayton campus
Publications - 93
Citations - 6394
Irina Caminschi is an academic researcher from Monash University, Clayton campus. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 37, co-authored 87 publications receiving 5661 citations. Previous affiliations of Irina Caminschi include Sir Charles Gairdner Hospital & University of Western Australia.
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Journal ArticleDOI
Cross-presentation of viral and self antigens by skin-derived CD103 + dendritic cells
Sammy Bedoui,Paul G. Whitney,Jason Waithman,Jason Waithman,Liv Eidsmo,Linda M. Wakim,Irina Caminschi,Rhys S. Allan,Magdalena Wojtasiak,Ken Shortman,Francis R. Carbone,Andrew G. Brooks,William R. Heath,William R. Heath +13 more
TL;DR: It is shown that CD103+ DCs were the migratory subset most efficient at processing viral antigens into the major histocompatibility complex class I pathway, potentially through cross-presentation.
Journal ArticleDOI
The dendritic cell subtype restricted C-type lectin Clec9A is a target for vaccine enhancement
Irina Caminschi,Anna I Proietto,Fatma Ahmet,Susie Kitsoulis,Joo Shin Teh,Jennifer Chi Yi Lo,Alexandra Rizzitelli,Li Wu,David Vremec,Serani Lh van Dommelen,Ian K. Campbell,Eugene Maraskovsky,Hal Braley,Gayle M. Davey,Patricia L Mottram,Nicholas C. van de Velde,Kent Jensen,Andrew M. Lew,Mark D. Wright,William R. Heath,Ken Shortman,Mireille H. Lahoud +21 more
TL;DR: Targeting Ags to DCs with antibodies to Clec9A is a promising strategy to enhance the efficiency of vaccines, even in the absence of adjuvants.
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Mouse Plasmacytoid Cells Long-lived Cells, Heterogeneous in Surface Phenotype and Function, that Differentiate Into CD8+ Dendritic Cells Only after Microbial Stimulus
Meredith O'Keeffe,Hubertus Hochrein,David Vremec,Irina Caminschi,Joanna L. Miller,E. Margot Anders,Li-Li Wu,Mireille H. Lahoud,Sandrine Henri,Bernadette Scott,Paul J. Hertzog,Lilliana Tatarczuch,Ken Shortman +12 more
TL;DR: The kinetics of bromodeoxyuridine labeling and the results of transfer to normal recipient mice indicate that CD4− p-preDCs are the immediate precursors of CD4+ p- preDCs, and microbial infection induces a wave of production of a new DC subtype.
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Liver-Resident Memory CD8 + T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection.
Daniel Fernandez-Ruiz,Wei Yi Ng,Wei Yi Ng,Lauren E. Holz,Joel Z. Ma,Ali Zaid,Yik Chun Wong,Lei Shong Lau,Vanessa Mollard,Anton Cozijnsen,Nicholas Collins,Jessica Li,Jessica Li,Gayle M. Davey,Yu Kato,Sapna Devi,Roghieh Skandari,Michael Pauley,Jonathan H. Manton,Dale I. Godfrey,Asolina Braun,Szun S. Tay,Peck Szee Tan,Peck Szee Tan,David G. Bowen,Friedrich Koch-Nolte,Björn Rissiek,Francis R. Carbone,Brendan S. Crabb,Mireille H. Lahoud,Mireille H. Lahoud,Ian A. Cockburn,Scott N. Mueller,Patrick Bertolino,Geoffrey I. McFadden,Irina Caminschi,Irina Caminschi,William R. Heath +37 more
TL;DR: It is shown that by combining dendritic cell-targeted priming with liver inflammation and antigen recognition on hepatocytes, high frequencies of Trm cells could be induced and these cells were essential for protection against malaria sporozoite challenge.
Journal ArticleDOI
The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments
Jian-Guo Zhang,Jian-Guo Zhang,Peter E. Czabotar,Peter E. Czabotar,Antonia N. Policheni,Antonia N. Policheni,Irina Caminschi,Irina Caminschi,Irina Caminschi,Soo San Wan,Susie Kitsoulis,Susie Kitsoulis,Kirsteen M. Tullett,Kirsteen M. Tullett,Adeline Y. Robin,Adeline Y. Robin,Rajini Brammananth,Mark F. van Delft,Mark F. van Delft,Jinhua Lu,Lorraine A. O'Reilly,Lorraine A. O'Reilly,Emma C. Josefsson,Emma C. Josefsson,Benjamin T. Kile,Benjamin T. Kile,Wei Jin Chin,Wei Jin Chin,Justine D. Mintern,Justine D. Mintern,Maya A. Olshina,Maya A. Olshina,Wilson Wong,Jake Baum,Jake Baum,Mark D. Wright,David C.S. Huang,David C.S. Huang,Narla Mohandas,Ross L. Coppel,Peter M. Colman,Peter M. Colman,Nicos A. Nicola,Nicos A. Nicola,Ken Shortman,Ken Shortman,Mireille H. Lahoud,Mireille H. Lahoud,Mireille H. Lahoud +48 more
TL;DR: It is proposed that Clec9A provides targeted recruitment of the adaptive immune system during infection and can also be utilized to enhance immune responses generated by vaccines.