Jau Yi Li

TL;DR: It is shown that a single dose of Ngal, introduced during the initial phase of the disease, dramatically protects the kidney and mitigates azotemia, and it provides a unique method for their treatment.

TL;DR: Current knowledge about the dual effects of NGAL as a siderophore:iron-binding protein and as a growth factor are summarized and the role of these effects in renal injury is examined.

TL;DR: It is shown that a member of the lipocalin superfamily (24p3/Ngal) delivers iron to the cytoplasm where it activates or represses iron-responsive genes and identifies an iron delivery pathway active in development and cell physiology.

TL;DR: Chimeras developed implicate cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways.

TL;DR: NGAL is rapidly and massively induced in renal epithelial injury and NGAL: siderophore: iron complexes may comprise a physiological renoprotective mechanism, which has implications for the diagnosis and treatment of acute renal injury.