R
Roland K. Strong
Researcher at Fred Hutchinson Cancer Research Center
Publications - 126
Citations - 13622
Roland K. Strong is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Siderocalin & MHC class I. The author has an hindex of 54, co-authored 120 publications receiving 12430 citations. Previous affiliations of Roland K. Strong include Center for International Blood and Marrow Transplant Research.
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Journal ArticleDOI
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron.
Trude Helen Flo,Kelly D. Smith,Kelly D. Smith,Shintaro Sato,David J. Rodriguez,Margaret A. Holmes,Roland K. Strong,Shizuo Akira,Alan Aderem +8 more
TL;DR: This finding represents a new component of the innate immune system and the acute phase response to infection and limits bacterial growth by sequestrating the iron-laden siderophore.
Journal ArticleDOI
The Neutrophil Lipocalin NGAL Is a Bacteriostatic Agent that Interferes with Siderophore-Mediated Iron Acquisition
David H. Goetz,Margaret A. Holmes,Niels Borregaard,Martin E. Bluhm,Kenneth N. Raymond,Roland K. Strong +5 more
TL;DR: It is proposed that NGAL participates in the antibacterial iron depletion strategy of the innate immune system by tightly binds bacterial catecholate-type ferric siderophores through a cyclically permuted, hybrid electrostatic/cation-pi interaction and is a potent bacteriostatic agent in iron-limiting conditions.
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An iron delivery pathway mediated by a lipocalin
Jun Yang,David H. Goetz,Jau Yi Li,Wenge Wang,Kiyoshi Mori,Daria Setlik,Tonggong Du,Hediye Erdjument-Bromage,Paul Tempst,Roland K. Strong,Jonathan Barasch +10 more
TL;DR: It is shown that a member of the lipocalin superfamily (24p3/Ngal) delivers iron to the cytoplasm where it activates or represses iron-responsive genes and identifies an iron delivery pathway active in development and cell physiology.
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Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family
Alexander Steinle,Pingwei Li,Daniel L. Morris,Veronika Groh,Lewis L. Lanier,Roland K. Strong,Thomas Spies +6 more
TL;DR: Comparison of allelic variants of MICA revealed large differences in NKG2D binding that were associated with a single amino acid substitution at position 129 in the α2 domain, which indicated promiscuous modes of receptor binding.
Journal ArticleDOI
Proof of principle for epitope-focused vaccine design
Bruno E. Correia,John T. Bates,Rebecca J. Loomis,Gretchen Baneyx,Chris Carrico,Joseph G. Jardine,Peter B. Rupert,Colin Correnti,Oleksandr Kalyuzhniy,Vinayak Vittal,Mary J. Connell,Eric Stevens,Alexandria Schroeter,Man Chen,Skye MacPherson,Andreia M. Serra,Yumiko Adachi,Margaret A. Holmes,Yuxing Li,Rachel E. Klevit,Barney S. Graham,Richard T. Wyatt,David Baker,Roland K. Strong,James E. Crowe,Philip R. Johnson,William R. Schief +26 more
TL;DR: In this paper, computational protein design can generate small, thermally and conformationally stable protein scaffolds that accurately mimic the viral epitope structure and induce potent neutralizing antibodies.