J
Javier Carrasco
Researcher at Autonomous University of Barcelona
Publications - 62
Citations - 3093
Javier Carrasco is an academic researcher from Autonomous University of Barcelona. The author has contributed to research in topics: Metallothionein & Astrocyte. The author has an hindex of 34, co-authored 61 publications receiving 2947 citations. Previous affiliations of Javier Carrasco include Carlos III Health Institute & Scripps Research Institute.
Papers
More filters
Journal ArticleDOI
Strongly compromised inflammatory response to brain injury in interleukin‐6‐deficient mice
Milena Penkowa,Torben Moos,Javier Carrasco,Hanne Hadberg,Amalia Molinero,Horst Bluethmann,Juan Hidalgo +6 more
TL;DR: It is demonstrated that IL‐6 is crucial for the recruitment of myelo‐monocytes and activation of glial cells following brain injury with disrupted BBB and the opposing effect of IL‐ 6 on MT‐I+II and MT‐III levels in the damaged brain suggests MT isoform‐specific functions.
Journal ArticleDOI
Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice.
TL;DR: The changes in neuronal tissue damage and in brain regeneration observed in IL‐6KO mice are likely caused by the IL-6‐dependent decrease in MT‐I+II expression, indicating IL‐ 6 and MT‐i+II as neuroprotective factors during brain injury.
Journal ArticleDOI
CNS Wound Healing Is Severely Depressed in Metallothionein I- and II-Deficient Mice
TL;DR: It is demonstrated that metallothioneins I and II are essential for a normal wound repair in the CNS, and that their deficiency impairs neuronal survival.
Journal ArticleDOI
Redefining the Role of Metallothionein within the Injured Brain: EXTRACELLULAR METALLOTHIONEINS PLAY AN IMPORTANT ROLE IN THE ASTROCYTE-NEURON RESPONSE TO INJURY*
Roger S. Chung,Milena Penkowa,Justin Dittmann,Carolyn E. King,Carole A. Bartlett,Johanne W. Asmussen,Juan Hidalgo,Javier Carrasco,Yee Kee J. Leung,Adam K. Walker,SJ Fung,Sarah A. Dunlop,Melinda Fitzgerald,Lyn Beazley,Meng Inn Chuah,James C. Vickers,Adrian K. West +16 more
TL;DR: Evidence is provided for a fundamentally different mode of action relying upon intercellular transfer from astrocytes to neurons, which in turn leads to uptake-dependent axonal regeneration and suggests that the protective functions of MT in the central nervous system should be widened to include extracellular and intra-neuronal roles.
Journal ArticleDOI
Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures.
TL;DR: It is demonstrated that interleukin-6 deficiency increases neuronal injury and impairs the inflammatory response after kainic acid-induced seizures, and that reactive astrogliosis and microgliosis were reduced, while morphological hippocampal damage, oxidative stress and apoptotic neuronal death were increased.