Jay R. Perrier

TL;DR: This is the first study to identify radiation-induced human protein signatures in vivo using the humanized mouse model and develop a protein panel which could be used for the rapid assessment of absorbed dose 3 days after radiation exposure.

TL;DR: A novel, high-throughput RABiT-IFC CBMN assay that possesses the potential to increase capacity for triage biodosimetry during a large-scale radiological/nuclear event is presented.

TL;DR: The overall goal is to extend the RABiT system to directly measure the kinetics of DNA repair proteins, and to demonstrate the scalability of the laboratory-based RAB iT system, a population study is initiated using γ-H2AX as a biomarker.

TL;DR: The γ-H2AX biomarker showed higher sensitivity to measure dose-rate effects after low-dose LDR X rays compared to MNi formation; however, confounding factors such as variable repair times post exposure, increased cell killing and cell cycle block likely contributed to the yields of MNi with accumulating doses of ionizing radiation.

TL;DR: A high-throughput micronucleus assay with automated scanning and imaging software on ex-vivo irradiated human lymphocytes is used to reconstruct partial-body and/or neutron exposure and estimate separately the photon and neutron doses in a mixed exposure, demonstrating a proof-of-principle for the proposed approach of high- Throughput reconstruction of clinically-relevant complex radiation exposure scenarios.