J
Jayendra Shinde
Researcher at Stanford University
Publications - 7
Citations - 1759
Jayendra Shinde is an academic researcher from Stanford University. The author has contributed to research in topics: DNA Mutational Analysis & Exome. The author has an hindex of 5, co-authored 6 publications receiving 1278 citations. Previous affiliations of Jayendra Shinde include Paris Descartes University.
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Journal ArticleDOI
Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
Kornelius Schulze,Sandrine Imbeaud,Eric Letouzé,Ludmil B. Alexandrov,Ludmil B. Alexandrov,Julien Calderaro,Sandra Rebouissou,Gabrielle Couchy,Clément Meiller,Jayendra Shinde,Frédéric Soysouvanh,Anna Line Calatayud,Roser Pinyol,Laura Pelletier,Charles Balabaud,Alexis Laurent,Jean-Frédéric Blanc,Vincenzo Mazzaferro,Fabien Calvo,Augusto Villanueva,Jean-Charles Nault,Paulette Bioulac-Sage,Michael R. Stratton,Josep M. Llovet,Josep M. Llovet,Jessica Zucman-Rossi +25 more
TL;DR: Exome sequencing analysis of 243 liver tumors identified mutational signatures associated with specific risk factors, mainly combined alcohol and tobacco consumption and exposure to aflatoxin B1, and defined the extensive landscape of altered genes and pathways in HCC.
Journal ArticleDOI
Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis.
Eric Letouzé,Jayendra Shinde,Victor Renault,Gabrielle Couchy,Jean-Frédéric Blanc,Emmanuel Tubacher,Quentin Bayard,Delphine Bacq,Vincent Meyer,Jérémy Semhoun,Paulette Bioulac-Sage,Sophie Prevot,Daniel Azoulay,Valérie Paradis,Sandrine Imbeaud,Jean-François Deleuze,Jessica Zucman-Rossi +16 more
TL;DR: Analysis of the whole genomes of 44 new and 264 published liver cancers reveals the evolution of mutational signatures during tumor development, highlighting mutational and structural signatures linked to environmental exposures and endogenous cellular processes.
Journal ArticleDOI
Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas.
Camilla Pilati,Jayendra Shinde,Ludmil B. Alexandrov,Guillaume Assié,Thierry André,Zofia Hélias-Rodzewicz,Romain Ducoudray,Delphine Le Corre,Jessica Zucman-Rossi,Jean-François Emile,Jérôme Bertherat,Eric Letouzé,Pierre Laurent-Puig +12 more
TL;DR: It is demonstrated that MUTYH inactivation results in a particular mutational signature, which may serve as a useful marker of BER‐related genomic instability in new cancer types.
Journal ArticleDOI
Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress
Quentin Bayard,Léa Meunier,Camille Peneau,Victor Renault,Jayendra Shinde,Jean-Charles Nault,Iadh Mami,Gabrielle Couchy,Giuliana Amaddeo,Emmanuel Tubacher,Delphine Bacq,Vincent Meyer,Tiziana La Bella,Audrey Debaillon-Vesque,Paulette Bioulac-Sage,Olivier Seror,Jean-Frédéric Blanc,Julien Calderaro,Jean-François Deleuze,Sandrine Imbeaud,Jessica Zucman-Rossi,Eric Letouzé +21 more
TL;DR: A new poor prognosis HCC entity and a rearrangement signature related to replication stress are revealed and pan-cancer analysis reveals a similar signature in BRCA1-mutated breast and ovarian cancers.
Journal ArticleDOI
Palimpsest: an R package for studying mutational and structural variant signatures along clonal evolution in cancer.
Jayendra Shinde,Quentin Bayard,Sandrine Imbeaud,Théo Z. Hirsch,Feng Liu,Victor Renault,Jessica Zucman-Rossi,Eric Letouzé +7 more
TL;DR: The Palimpsest R package provides a complete workflow for the characterization and visualization of mutational signatures and their evolution along tumor development, covering a wide range of functions for extracting both base substitution and structural variant signatures.