J
Jean-Claude Drapier
Researcher at Institut de Chimie des Substances Naturelles
Publications - 35
Citations - 1670
Jean-Claude Drapier is an academic researcher from Institut de Chimie des Substances Naturelles. The author has contributed to research in topics: Aconitase & Nitric oxide. The author has an hindex of 22, co-authored 35 publications receiving 1571 citations. Previous affiliations of Jean-Claude Drapier include Polish Academy of Sciences & Centre national de la recherche scientifique.
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Journal ArticleDOI
Friedreich ataxia: the oxidative stress paradox
Hervé Seznec,Delphine Simon,Cécile Bouton,Laurence Reutenauer,Ariane Hertzog,Pawel Golik,Vincent Procaccio,Manisha Patel,Jean-Claude Drapier,Michel Koenig,Hélène Puccio +10 more
TL;DR: The data demonstrate that in FRDA, mitochondrial iron accumulation does not induce oxidative stress and propose that, contrary to the general assumption, FRDA is a neurodegenerative disease not associated with oxidative damage.
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Monitoring in Real Time with a Microelectrode the Release of Reactive Oxygen and Nitrogen Species by a Single Macrophage Stimulated by its Membrane Mechanical Depolarization
Christian Amatore,Stéphane Arbault,Cécile Bouton,Karen Coffi,Jean-Claude Drapier,Hala Ghandour,Yuehong Tong +6 more
TL;DR: The aim of the present work was to study the fundamental mechanism of oxidant release by macrophages at the level of a single cell, in real time and quantitatively, and to calculate the calculation of time variations of emission flux for each species and the reconstruction of the original flux of production of primary species, O2.− and NO.
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Regulation of Peroxiredoxins by Nitric Oxide in Immunostimulated Macrophages
Alexandre Diet,Kahina Abbas,Cécile Bouton,Blanche Guillon,Flora Tomasello,Simon Fourquet,Michel B. Toledano,Jean-Claude Drapier +7 more
TL;DR: Modulation by NO of Prx expression and redox state, as well as up-regulation of Srx expression, constitutes a novel pathway that contributes to antioxidant response and control of H2O2-mediated signal transduction in mammals.
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Real-time amperometric analysis of reactive oxygen and nitrogen species released by single immunostimulated macrophages.
Christian Amatore,Stéphane Arbault,Cécile Bouton,Jean-Claude Drapier,Hala Ghandour,Alaric C.W. Koh +5 more
TL;DR: Direct evidence for the formation of ONOO− in stimulated macrophages is presented and the presence of 1400W, a selective inducible nitric oxide synthase (iNOS) inhibitor, led to an almost complete attenuation of the amperometric response of activated RAW 264.7 cells.
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The Diabetes Drug Target MitoNEET Governs a Novel Trafficking Pathway to Rebuild an Fe-S Cluster into Cytosolic Aconitase/Iron Regulatory Protein 1
Ioana Ferecatu,Sergio Gonçalves,Marie-Pierre Golinelli-Cohen,Marie-Pierre Golinelli-Cohen,Martin Clémancey,Alain Martelli,Sylvie Riquier,Eric Guittet,Jean-Marc Latour,Hélène Puccio,Jean-Claude Drapier,Ewen Lescop,Cécile Bouton +12 more
TL;DR: Fe-S assembly of mitoNEET, the first identified Fe-S protein anchored in the mitochondrial outer membrane, strictly depends on ISC machineries and not on the CIA or CIAPIN1.