J
Jean Costentin
Researcher at University of Rouen
Publications - 300
Citations - 13606
Jean Costentin is an academic researcher from University of Rouen. The author has contributed to research in topics: Dopamine & Dopaminergic. The author has an hindex of 51, co-authored 299 publications receiving 13169 citations. Previous affiliations of Jean Costentin include Académie Nationale de Médecine & Centre national de la recherche scientifique.
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Unexpected potentiation by discriminant benzamide derivatives of stereotyped behaviours elicited by dopamine agonists in mice.
TL;DR: For the various DBD, the two stereotyped behaviours emerge at dosages at which climbing starts to be inhibited, suggesting that selective blockade of some inhibitory response to APO is responsible for the potentiation.
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Synthesis and biological effects of c(Lys-Lys-Pro-Tyr-Ile-Leu-Lys-Lys-Pro-Tyr-Ile-Leu) (JMV2012), a new analogue of neurotensin that crosses the blood-brain barrier.
Pierre Bredeloux,Florine Cavelier,Isabelle Dubuc,Bertrand Vivet,Jean Costentin,Jean Martinez +5 more
TL;DR: In mice, compound 1 induced a profound hypothermia and a potent analgesia, even when peripherally administered, suggesting the peptide penetrates the blood-brain barrier and functions effectively like a drug.
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Acute effects of direct dopamine agonists in the mouse behavioral despair test
TL;DR: All the dopamine agonists tested in the 'behavioral despair' test performed in mice had a dose-dependent anti-immobility effect, with the exception of the D-1 dopamine agonist, SKF 38393.
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Ionic requirements for the specific binding of [3H]GBR 12783 to a site associated with the dopamine uptake carrier.
TL;DR: The results suggest that low Na+ concentrations are required for maximal binding; higherNa+ concentrations protect the specific binding site against the inhibitory effect of other cations.
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Antagonism of the apomorphine-induced yawning by "atypical" neuroleptics.
TL;DR: By combining apomorphine- and physostigmine-induced yawning, it is possible to assess the anticholinergic component in the antagonism of this effect of apomorphicine and this may be of value for the understanding of the mechanisms underlying the "atypical" character.