J
Jean Costentin
Researcher at University of Rouen
Publications - 300
Citations - 13606
Jean Costentin is an academic researcher from University of Rouen. The author has contributed to research in topics: Dopamine & Dopaminergic. The author has an hindex of 51, co-authored 299 publications receiving 13169 citations. Previous affiliations of Jean Costentin include Académie Nationale de Médecine & Centre national de la recherche scientifique.
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Apparent opposite effects of tetrabenazine and reserpine on the toxic effects of 1-methyl-4-phenylpyridinium or 6-hydroxydopamine on nigro-striatal dopaminergic neurons.
TL;DR: VMAT2 inhibition potentiates both MPP(+) and 6-OHDA neurotoxicity, and the influence of hypothermia on the toxic activity of both neurotoxins is investigated.
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Involvement of the NH2 terminal domain of catecholamine transporters in the Na+ and Cl−‐dependence of a [3H]‐dopamine uptake
TL;DR: The ionic dependence of the [3H]‐dopamine uptake was studied in transfected cells expressing the human neuronal transporter for dopamine or noradrenaline, and chimeric transporters resulting from the symmetrical exchange of the region from the NH2 terminal through the first two transmembrane domains (cassette I).
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Synthesis and preliminary study of the activity of thiophene analogues of pyrovalerone on the neuronal uptake of the monoamines
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Desensitization of μ-opioid receptors does not modify the analgesia induced by an enkephalinase inhibitor
TL;DR: The results suggest that the enkephalins protected by acetorphan act on the delta receptor site to produce antinociception.
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Recovery of dopamine neuronal transporter but lack of change of its mRNA in substantia nigra after inactivation by a new irreversible inhibitor characterized in vitro and ex vivo in the rat.
TL;DR: The results indicate that DEEP‐NCS behaves as a potent, quite selective, irreversible inhibitor of the DAT, in vitro and in vivo, and suggests that the physiological half‐life of the rat striatal DAT is close to 6 days.