J
Jean Costentin
Researcher at University of Rouen
Publications - 300
Citations - 13606
Jean Costentin is an academic researcher from University of Rouen. The author has contributed to research in topics: Dopamine & Dopaminergic. The author has an hindex of 51, co-authored 299 publications receiving 13169 citations. Previous affiliations of Jean Costentin include Académie Nationale de Médecine & Centre national de la recherche scientifique.
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Pharmacology of enkephalinase inhibitors
TL;DR: The pharmacology of the new enkephalinase inhibitors which appears to be related to enhancement of opioid activity is discussed, and the problems with this approach centre on the lack of biochemical selectivity of the peptidase.
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Individual differences in response to imipramine in the mouse tail suspension test
TL;DR: Control for individual differences in the spontaneous performance in this animal model of depression may provide a useful tool to study behavioural, neurochemical and neuroendocrine correlates of antidepressant action.
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The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: a randomized crossover clinical trial.
Jean-Christophe Corvol,Cecilia Bonnet,Fanny Charbonnier-Beaupel,Anne-Marie Bonnet,Marie-Hélène Fievet,Agnès Bellanger,Emmanuel Roze,Gayané Meliksetyan,Mouna Ben Djebara,Andreas Hartmann,Lucette Lacomblez,Lucette Lacomblez,Cédric Vrignaud,Noël Zahr,Yves Agid,Yves Agid,Jean Costentin,Jean-Sébastien Hulot,Marie Vidailhet +18 more
TL;DR: The objective of this study was to determine the response to entacapone in COMTHH and COMTLL PD patients.
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Absence of the adenosine A2A receptor or its chronic blockade decrease ethanol withdrawal-induced seizures in mice
TL;DR: The results suggest that selective adenosine A(2A) receptor antagonists may be useful in the treatment of alcohol withdrawal.
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The octadecaneuropeptide [diazepam-binding inhibitor (33–50)] exerts potent anorexigenic effects in rodents
Juana Garcia de Mateos-Verchere,Jérôme Leprince,Marie-Christine Tonon,Hubert Vaudry,Jean Costentin +4 more
TL;DR: The present data demonstrate that i.v. c.c. injection of ODN causes, in both rat and mouse, a long-lasting anorexigenic effect that is not mediated through central-type benzodiazepine receptors.