Jean-Denis Bignon

TL;DR: Screening of HLA antibodies posttransplantation could be a good tool for the follow-up of patients who receive a kidney transplant and allow immunosuppression to be tailored.

TL;DR: The findings confirm the implication of the cationic trypsinogen gene in HP and highlight allelic diversity associated with this phenotype and show that the pattern of inheritance of HP is probably complex and that other genes may be involved in this genetic disease.

TL;DR: A large French family from a four-generation kindred with HP has been examined and a genome segregation analysis of highly informative microsatellite markers has been performed, indicating the most likely order for the Hereditary Pancreatitis Gene (HPG) is D7S 640-D 7S 495-D7S 684-D8S 661-D9S 676-D6S 688, with the HP gene situated in the underlined region.

TL;DR: negative effects of HLA mismatching for either HLA-A, -B, -C, -DRB1, or -DQB1 loci on survival are demonstrated, and "Missing killer cell immunoglobulin-like receptor (KIR) ligand" evaluated on the presence of Hla-C2, and Bw4 groups in the recipients was not associated with aGVHD, survival, and relapse in this cohort of non-T cell-depleted HS

TL;DR: The 18 immunized mothers studied here by restriction fragment length polymorphism analysis had the DRw52a specificity at the DRb3 locus whatever their HLA-DRB1 gene product, which strongly suggests that the DRB3 chain is directly involved in the presentation of the PL-A1 antigen to the specific T cell.