Jean-Jacques Grob

TL;DR: EP increases the effect of intralesional bleomycin and improves the rate of local control in melanoma skin metastases without inducing a more systemic effect, which could be useful in a palliative strategy in patients with melanomaskin metastases.

TL;DR: Previous analysis of COMBI-d showed that D+T compared with D monotherapy improved ORR and reduced risk of adverse events, and this analysis confirms this finding.

TL;DR: It appears likely that cells expressing the tyrosinase gene are present in a wide range of human tissues, although these cells still have to be accurately identified, one could propose that they might correspond to either fully differentiated melanocytes, melanocytic precursors, or Schwann cells bearing potentialities of melanocytical differentiation.

TL;DR: The results show that Lysate-DC therapy elicited tumor-specific CD8+ T cells nonlimited to human leukocyte antigen-A2+ patients, with some T cells secreting perforin ex vivo and IFN-γ only after restimulation, which supports that the sole use of IFn-γ production to monitor T cells overlooks functional T-cell subpopulations triggered by vaccines.

TL;DR: Education by photographs is a realistic strategy which should replace or complete “ABCD” message in the campaigns for self‐detection of MM and a quick look at a few photographs is sufficient to improve the ability of the laymen to recognize a MM just by optimizing their spontaneous image recognition capacities.