J
Jean N. Buskin
Researcher at University of Washington
Publications - 15
Citations - 3720
Jean N. Buskin is an academic researcher from University of Washington. The author has contributed to research in topics: Myocyte & Enhancer. The author has an hindex of 13, co-authored 15 publications receiving 3677 citations.
Papers
More filters
Journal ArticleDOI
Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence.
Cornelis Murre,Patrick S. McCaw,H. Vaessin,M. Caudy,Lily Yeh Jan,Yuh Nung Jan,Carlos V. Cabrera,Jean N. Buskin,Stephen D. Hauschka,Andrew B. Lassar,Harold Weintraub,David Baltimore +11 more
TL;DR: The HLH domain can mediate heterodimer formation between either daughterless, E12, or E47 and achaete-scute T3 or MyoD to form proteins with high affinity for the kappa E2 site in the immunoglobulin kappa chain enhancer.
Journal ArticleDOI
MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer
Andrew B. Lassar,Jean N. Buskin,Daniel Lockshon,Robert L. Davis,Stephen Apone,Stephen D. Hauschka,Harold Weintraub +6 more
TL;DR: It is shown that MyoD is a DNA binding protein capable of specific interaction with two regions of the mouse muscle creatine kinase gene upstream enhancer, both of which are required for full muscle-specific enhancer activity.
Journal ArticleDOI
Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene.
TL;DR: The muscle creatine kinase gene is transcriptionally induced when skeletal muscle myoblasts differentiate into myocytes and the factor which interacts with the two MCK enhancers myocyte-specific enhancer-binding nuclear factor 1 (MEF 1) is designated.
Journal ArticleDOI
The muscle creatine kinase gene is regulated by multiple upstream elements, including a muscle-specific enhancer.
TL;DR: Comparisons of viral and cellular enhancer sequences with the mouse MCK enhancer revealed some similarities to essential regions of the simian virus 40 enhancer as well as to a region of the immunoglobulin heavy-chain enhancer, which has been implicated in tissue-specific protein binding.
Journal ArticleDOI
Transcriptional regulation of the muscle creatine kinase gene and regulated expression in transfected mouse myoblasts.
TL;DR: It is suggested that coordinate control of a subset of muscle genes may occur via recognition of these common sequences in the alpha-actin and myOSin heavy chain genes, but not in the myosin light-chain genes, with the regions containing these repeats.