J
Jean-Pierre Boissel
Researcher at Centre national de la recherche scientifique
Publications - 21
Citations - 2283
Jean-Pierre Boissel is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Population & Randomized controlled trial. The author has an hindex of 11, co-authored 21 publications receiving 2204 citations. Previous affiliations of Jean-Pierre Boissel include University of Lyon & Claude Bernard University Lyon 1.
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Journal ArticleDOI
Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials
Jan A. Staessen,Jerzy Gasowski,Jerzy Gasowski,Ji G. Wang,Ji G. Wang,Lutgarde Thijs,Elly Den Hond,Jean-Pierre Boissel,John Coope,Tork Ekbom,François Gueyffier,Lisheng Liu,Karla Kerlikowske,Stuart J. Pocock,Robert Fagard +14 more
TL;DR: Drug treatment is justified in older patients with isolated systolic hypertension whose systolics blood pressure is 160 mm Hg or higher and in those with previous cardiovascular complications or wider pulse pressure, suggesting the coronary protection may have been underestimated.
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Antihypertensive drugs in very old people: a subgroup meta-analysis of randomised controlled trials
François Gueyffier,Christopher J. Bulpitt,Jean-Pierre Boissel,Eleanor Schron,Tord Ekbom,Robert Fagard,Edoardo Casiglia,Karla Kerlikowske,John Coope +8 more
TL;DR: Results of a large-scale specific trial are needed for definite conclusion that antihypertensive treatment is beneficial in very elderly hypertensive patients, as an age threshold beyond which hypertension should not be treated cannot be justified.
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Reappraisal of Metformin Efficacy in the Treatment of Type 2 Diabetes: A Meta-Analysis of Randomised Controlled Trials
Rémy Boussageon,Irène Supper,Theodora Bejan-Angoulvant,Nadir Kellou,Michel Cucherat,Michel Cucherat,Jean-Pierre Boissel,Jean-Pierre Boissel,Behrouz Kassai,Alain Moreau,François Gueyffier,Catherine Cornu +11 more
TL;DR: It is shown that although metformin is considered the gold standard, its benefit/risk ratio remains uncertain and its effect on cardiovascular morbidity or mortality in patients with type 2 diabetes is still uncertain.
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Efficacy of treating hypertension in women.
TL;DR: Hypertension treatment lowers the relative and absolute risk of cardiovascular morbidity and mortality in women aged 55 years and older and in African-American women of all ages.
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Role of astrocytes in grey matter during stroke: a modelling approach.
TL;DR: Astrocytes are shown to contribute to the excitotoxicity process by expelling glutamate out of the cells via the reversed glutamate transporter, and appear to be unable to maintain potassium homeostasis under conditions of severe ischaemia.