J
Jean Chappel
Researcher at Washington University in St. Louis
Publications - 34
Citations - 2811
Jean Chappel is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Osteoclast & Bone resorption. The author has an hindex of 23, co-authored 34 publications receiving 2689 citations. Previous affiliations of Jean Chappel include Jewish Hospital.
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Journal ArticleDOI
Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption.
F. P. Ross,Jean Chappel,J. Alvarez,D. Sander,W. T. Butler,Mary C. Farach-Carson,K. A. Mintz,Pamela Gehron Robey,Steven L. Teitelbaum,David A. Cheresh +9 more
TL;DR: It is concluded that both osteoclast adherence to bone and subsequent resorption of its matrix are dependent on interactions between the bone matrix proteins osteopontin and/or bone sialoprotein and the integrin alpha v beta 3.
Journal ArticleDOI
G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow
Craig L. Semerad,Matthew J. Christopher,Fulu Liu,Brenton Short,Paul J. Simmons,Ingrid G. Winkler,Jean-Pierre Levesque,Jean Chappel,F. Patrick Ross,Daniel C. Link +9 more
TL;DR: Data suggest a model in which G-CSF, through an indirect mechanism, potently inhibits osteoblast activity resulting in decreased CXCL12 expression in the bone marrow, which ultimately leads to HPC mobilization.
Journal ArticleDOI
Vav3 regulates osteoclast function and bone mass
Roberta Faccio,Roberta Faccio,Steven L. Teitelbaum,Keiko Fujikawa,Keiko Fujikawa,Jean Chappel,Alberta Zallone,Victor L. J. Tybulewicz,F. Patrick Ross,Wojciech Swat +9 more
TL;DR: Vav3-deficient mice have increased bone mass and are protected from bone loss induced by systemic bone resorption stimuli such as parathyroid hormone or RANKL, and is a potential new target for antiosteoporosis therapy.
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Cloning of the promoter for the avian integrin beta 3 subunit gene and its regulation by 1,25-dihydroxyvitamin D3.
TL;DR: In light of the observation that 1,25-dihydroxyvitamin D3 (D3) accelerates beta 3 transcription, it is determined whether the avian beta 3 promoter contains a vitamin D response element (VDRE).
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Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion
TL;DR: In the present study, it is shown that synaptotagmin VII, a calcium sensor protein that regulates exocytosis, is associated with lysosomes in osteoclasts and bone matrix protein-containing vesicles in osteoblasts, and plays an important role in bone remodeling and homeostasis.