Jeannette E. Doeller

TL;DR: It is demonstrated that the delivery of H2S at the time of reperfusion limits infarct size and preserves left ventricular (LV) function in an in vivo model of myocardial ischemia-reperfusion (MI-R) and that either administration of H 2S or the modulation of endogenous production may be of clinical benefit in ischemic disorders.

TL;DR: It is shown that human RBCs convert garlic-derived organic polysulfides into hydrogen sulfide (H2S), an endogenous cardioprotective vascular cell signaling molecule, strongly supporting the hypothesis that H2S mediates the vasoactivity of garlic.

TL;DR: The use of a novel polarographic H2S sensor (PHSS) to follow rapid changes in H2s concentration in common buffered biological solutions with a detection limit near 10 nM is demonstrated and suggests the existence of dynamic steady-state cellular H 2S levels.

TL;DR: It is hypothesized that mitochondrial defects induced by exposure to a HFD (high fat diet) contribute to a hypoxic state in liver and this is associated with increased protein modification by RNS (reactive nitrogen species).

TL;DR: In rat aorta, H( 2)S concentrations that mediate rapid contraction at high O(2) levels cause rapid relaxation at lower physiological O(1) levels, suggesting that it may be a putative vasoactive oxidation product that mediates constriction that modulates vascular tone in vivo.