J
Jack R. Lancaster
Researcher at University of Pittsburgh
Publications - 106
Citations - 11813
Jack R. Lancaster is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Nitric oxide & Nitrite. The author has an hindex of 48, co-authored 106 publications receiving 11033 citations. Previous affiliations of Jack R. Lancaster include Washington University in St. Louis & University of Alabama at Birmingham.
Papers
More filters
Journal ArticleDOI
The biological lifetime of nitric oxide: Implications for the perivascular dynamics of NO and O2
TL;DR: Computer modeling reveals that this phenomenon, coupled with reversible NO inhibition of cellular mitochondrial oxygen consumption, substantially extends the zone of adequate tissue cellular oxygenation away from the blood vessel, with an especially dramatic effect during conditions of increased tissue work.
Journal ArticleDOI
Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction
John A. Corbett,Ronald G. Tilton,Kathy Chang,Khalid S Hasan,Yasuo Ido,Jin Lin Wang,Michael A. Sweetland,Jack R. Lancaster,Joseph R. Williamson,Michael L. McDaniel +9 more
TL;DR: It is demonstrated that aminoguanidine inhibits NO.
Journal ArticleDOI
The emerging biology of the nitrite anion
Mark T. Gladwin,Alan N. Schechter,Daniel B. Kim-Shapiro,Rakesh P. Patel,Neil Hogg,Sruti Shiva,Richard O. Cannon,Malte Kelm,David A. Wink,Michael Graham Espey,Edward H. Oldfield,Ryszard M. Pluta,Bruce A. Freeman,Jack R. Lancaster,Martin Feelisch,Jon O. Lundberg +15 more
TL;DR: Nitrite has now been proposed to play an important physiological role in signaling, blood flow regulation and hypoxic nitric oxide homeostasis.
Journal ArticleDOI
Accelerated reaction of nitric oxide with O2 within the hydrophobic interior of biological membranes
TL;DR: It is concluded that biological membranes and other tissue hydrophobic compartments are important sites for disappearance of NO and for formation of NO-derived reactive species and that attenuation of these potentially damaging reactions is an important protective action of lipid-soluble antioxidants such as vitamin E.
Journal ArticleDOI
Nitrate and nitrite in biology, nutrition and therapeutics
Jon O. Lundberg,Mark T. Gladwin,Amrita Ahluwalia,Nigel Benjamin,Nathan S. Bryan,Anthony R. Butler,Pedro Cabrales,Angela Fago,Martin Feelisch,Peter C. Ford,Bruce A. Freeman,Michael P. Frenneaux,Joel M. Friedman,Malte Kelm,Christopher G. Kevil,Daniel B. Kim-Shapiro,Andrey V. Kozlov,Jack R. Lancaster,David J. Lefer,Kenneth E.L. McColl,Kenneth R. McCurry,Rakesh P. Patel,Joel Petersson,Tienush Rassaf,Valentin Reutov,George B. Richter-Addo,Alan N. Schechter,Sruti Shiva,Koichiro Tsuchiya,Ernst E. van Faassen,Andrew J. Webb,Brian S. Zuckerbraun,Jay L. Zweier,Eddie Weitzberg +33 more
TL;DR: The latest advances in the understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm.