J
Jef Rozenski
Researcher at Rega Institute for Medical Research
Publications - 215
Citations - 5519
Jef Rozenski is an academic researcher from Rega Institute for Medical Research. The author has contributed to research in topics: Oligonucleotide & Nucleic acid. The author has an hindex of 34, co-authored 209 publications receiving 4961 citations. Previous affiliations of Jef Rozenski include Katholieke Universiteit Leuven & Catholic University of Leuven.
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Journal ArticleDOI
The RNA modification database, RNAMDB: 2011 update
William A. Cantara,Pamela F. Crain,Jef Rozenski,James A. McCloskey,Kimberly A. Harris,Xiaonong Zhang,Franck A. P. Vendeix,Daniele Fabris,Paul F. Agris +8 more
TL;DR: The expanded future role of The RNA Modification Database will be to serve as a primary information portal for researchers across the entire spectrum of RNA-related research.
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Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.
Inna Kuperstein,Kerensa Broersen,Kerensa Broersen,Iryna Benilova,Iryna Benilova,Iryna Benilova,Jef Rozenski,Wim Jonckheere,Wim Jonckheere,Maja Debulpaep,Maja Debulpaep,Annelies Vandersteen,Annelies Vandersteen,Ine M.J. Segers-Nolten,Kees van der Werf,Vinod Subramaniam,Dries Braeken,Geert Callewaert,Carmen Bartic,Carmen Bartic,Rudi D'Hooge,Ivo C. Martins,Ivo C. Martins,Frederic Rousseau,Frederic Rousseau,Joost Schymkowitz,Joost Schymkowitz,Bart De Strooper,Bart De Strooper +28 more
TL;DR: It is shown that small alterations in the Aβ42:Aβ40 ratio dramatically affect the biophysical and biological properties of the A β mixtures reflected in their aggregation kinetics, the morphology of the resulting amyloid fibrils and synaptic function tested in vitro and in vivo.
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Gain of function of mutant p53 by coaggregation with multiple tumor suppressors
Jie Xu,Joke Reumers,José R. Couceiro,Frederik De Smet,Rodrigo Gallardo,Stanislav Rudyak,Ann Cornelis,Jef Rozenski,Aleksandra Zwolinska,Jean-Christophe Marine,Diether Lambrechts,Young-Ah Suh,Frederic Rousseau,Joost Schymkowitz +13 more
TL;DR: This study reveals a novel disease mechanism for mutant p53 gain of function and suggests that, at least in some respects, cancer could be considered an aggregation-associated disease.
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Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives.
T. Jonckers,Sabine Van Miert,K. Cimanga,Christian Bailly,Pierre Colson,Marie-Claire De Pauw-Gillet,Hilde Van den Heuvel,Magda Claeys,Filip Lemière,E. L. Esmans,Jef Rozenski,Ludo Quirijnen,Louis Maes,R. Dommisse,G. L. Lemière,A. Vlietinck,Luc Pieters +16 more
TL;DR: 2-bromoneocryptolepine is considered as the most promising lead from the present work for new antimalarial agents and exhibited antitrypanosomal activity in the micromolar range in the absence of obvious cytotoxicity.
Journal ArticleDOI
Synthesis, Biological Evaluation, and Structure Analysis of a Series of New 1,5-Anhydrohexitol Nucleosides
I. Verheggen,Arthur Van Aerschot,Luc Van Meervelt,Jef Rozenski,Leonard I. Wiebe,Robert Snoeck,Graciela Andrei,Jan Balzarini,Paul Claes +8 more
TL;DR: From a transport study of 1,5-anhydrohexitol 3, one can conclude that intracellular uptake of this compound most probably occurs by passive diffusion.