J
Jeffrey J. Lange
Researcher at Stowers Institute for Medical Research
Publications - 56
Citations - 912
Jeffrey J. Lange is an academic researcher from Stowers Institute for Medical Research. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 16, co-authored 46 publications receiving 651 citations. Previous affiliations of Jeffrey J. Lange include Washington University in St. Louis & Kansas State University.
Papers
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Journal ArticleDOI
Egr-5 is a post-mitotic regulator of planarian epidermal differentiation
Kimberly C. Tu,Li-Chun Cheng,Hanh Thi-Kim Vu,Jeffrey J. Lange,Sean A McKinney,Chris Seidel,Alejandro Sánchez Alvarado +6 more
TL;DR: The planarian epidermis is established as a novel paradigm to uncover the molecular mechanisms regulating ASC specification in vivo and a conserved early growth response family transcription factor, egr-5, that is essential for epidermal differentiation is identified.
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wtf genes are prolific dual poison-antidote meiotic drivers
Nicole L. Nuckolls,María Angélica Bravo Núñez,Michael T. Eickbush,Janet M. Young,Jeffrey J. Lange,Jonathan S Yu,Gerald R. Smith,Sue L. Jaspersen,Sue L. Jaspersen,Harmit S. Malik,Sarah E Zanders,Sarah E Zanders +11 more
TL;DR: A complex landscape of meiotic drive genes on chromosome 3 of the fission yeasts Schizosaccharomyces kambucha and S. pombe is demonstrated, suggesting that the wtf multigene family proliferated due to meioticDrive and highlights the power of selfish genes to shape genomes, even while imposing tremendous costs to fertility.
Journal ArticleDOI
The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex
Gunther Hollopeter,Jeffrey J. Lange,Ying Zhang,Thien N Vu,Mingyu Gu,Michael Ailion,Eric J. Lambie,Brian D. Slaughter,Jay R. Unruh,Laurence Florens,Erik M. Jorgensen +10 more
TL;DR: It is demonstrated that the membrane-associated proteins FCHo and SGIP1 convert AP2 into an open, active conformation by rearrangement of the F-BAR domain or the µ-homology domain that directly binds AP2.
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Quantifying Nucleation In Vivo Reveals the Physical Basis of Prion-like Phase Behavior
Tarique Khan,Tejbir S. Kandola,Jianzheng Wu,Jianzheng Wu,Shriram Venkatesan,Ellen Ketter,Jeffrey J. Lange,Alejandro Rodriguez Gama,Andrew C. Box,Jay R. Unruh,Malcolm Cook,Randal Halfmann,Randal Halfmann +12 more
TL;DR: It is shown that kinetic barriers limit the nucleation of ordered self-assemblies and that the persistence of the barriers with respect to concentration relates to structure, suggesting that nucleation barriers govern cytoplasmic inheritance, subcellular organization, and proteotoxicity.
Journal ArticleDOI
Dynamic regulation of Nanog and stem cell-signaling pathways by Hoxa1 during early neuro-ectodermal differentiation of ES cells
Bony De Kumar,Hugo J. Parker,Mark E. Parrish,Jeffrey J. Lange,Brian D. Slaughter,Jay R. Unruh,Ariel Paulson,Robb Krumlauf,Robb Krumlauf +8 more
TL;DR: A model whereby direct inputs of Nanog and Hoxa1 on shared targets and mutual repression between HoxA1 and the core pluripotency network provides a molecular mechanism that modulates the fine balance between the alternate states of pluripOTency and differentiation is proposed.