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Vanessa A. York

Researcher at University of California, San Francisco

Publications -  28
Citations -  2204

Vanessa A. York is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Interleukin 21 & Cytotoxic T cell. The author has an hindex of 16, co-authored 28 publications receiving 1842 citations. Previous affiliations of Vanessa A. York include University of California.

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Expansion of a unique CD57+NKG2Chi natural killer cell subset during acute human cytomegalovirus infection

TL;DR: The preferential expansion of a unique subset of NK cells coexpressing the activating CD94–NKG2C receptor and CD57 in CMV+ donors is demonstrated and it is proposed that CD57 might provide a marker of “memory” NK cells that have been expanded in response to infection.
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CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset

TL;DR: A combination of a mature phenotype, a higher cytotoxic capacity, aHigher sensitivity to stimulation via CD16, with a decreased responsiveness to cytokines, and a decreased capacity to proliferate suggest that CD57(+) NK cells are highly mature and might be terminally differentiated.
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Evaluation of SARS-CoV-2 serology assays reveals a range of test performance.

TL;DR: A head-to-head evaluation of ten point-of-care-style lateral flow assays and two laboratory-based enzyme-linked immunosorbent assays to detect anti-SARS-CoV-2 IgM and IgG antibodies in 5-d time intervals from symptom onset underline the importance of seropositivity threshold determination and reader training for reliable LFA deployment.
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CD56negCD16+NK cells are activated mature NK cells with impaired effector function during HIV-1 infection

TL;DR: It is found that CD3negCD56negCD16+ cells are a heterogeneous population comprised of CD7+ NK cells and CD7neg non-classical myeloid cells that may have recently engaged target cells.
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Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4

TL;DR: Novel subsets of peripheral blood CD3/14/19(neg) NK cells and monocyte/dendritic cell (DC)-like cells were identified on the basis of CD7 and CD4 expression to improve the ability to study the intricacies of NK-cell subset phenotypes and functions in vivo.