Jeffrey M. Milush

TL;DR: The preferential expansion of a unique subset of NK cells coexpressing the activating CD94–NKG2C receptor and CD57 in CMV+ donors is demonstrated and it is proposed that CD57 might provide a marker of “memory” NK cells that have been expanded in response to infection.

TL;DR: A combination of a mature phenotype, a higher cytotoxic capacity, aHigher sensitivity to stimulation via CD16, with a decreased responsiveness to cytokines, and a decreased capacity to proliferate suggest that CD57(+) NK cells are highly mature and might be terminally differentiated.

TL;DR: It is proposed that evolutionary adaptation to both preserve immune function with fewer mucosal CD4+ T cells and attenuate the immune activation that follows acute viral infection protect these animals from progressing to AIDS.

TL;DR: The FLIPS assay identified multiple identical intact proviruses, suggesting a role for cellular proliferation in the maintenance of the latent HIV-1 reservoir and addressing the limitations of other methods that also genetically characterize the latent reservoir.

TL;DR: Next-generation sequencing of near-full-length single HIV-1 genomes and corresponding chromosomal integration sites suggest that a distinct configuration of the proviral reservoir represents a structural correlate of natural viral control, and that the quality, rather than the quantity, of viral reservoirs can be an important distinguishing feature for a functional cure of HIV- 1 infection.