J
Jelmar Quist
Researcher at King's College London
Publications - 28
Citations - 539
Jelmar Quist is an academic researcher from King's College London. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 9, co-authored 20 publications receiving 354 citations. Previous affiliations of Jelmar Quist include Guy's Hospital & Brigham and Women's Hospital.
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Journal ArticleDOI
PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer
Fara Braso-Maristany,Simone Filosto,Steven Catchpole,Rebecca Marlow,Jelmar Quist,Erika Francesch-Domenech,Plumb Da,Zakka L,Patrycja Gazinska,Gianmaria Liccardi,Pascal Meier,Albert Gris-Oliver,Maggie C.U. Cheang,Perdrix-Rosell A,Manar S. Shafat,Elodie Noel,Nirmesh Patel,McEachern K,Maurizio Scaltriti,Pau Castel,Farzana Noor,Richard Buus,Sumi Mathew,Johnathan Watkins,Serra,Pierfrancesco Marra,Anita Grigoriadis,Andrew Tutt,Andrew Tutt +28 more
TL;DR: PIM1 is identified as a malignant-cell-selective target in TNBC and the potential use of PIM1 inhibitors for sensitizing TNBC to chemotherapy-induced apoptotic cell death is identified.
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Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6) in breast cancer.
Gabriele Corda,Gianluca Sala,Rossano Lattanzio,Manuela Iezzi,Michele Sallese,G Fragassi,Alessia Lamolinara,Hasan Mirza,Daniela Barcaroli,Sibylle Ermler,Elisabete Silva,Hemad Yasaei,Robert F. Newbold,Paola Vagnarelli,Marcella Mottolese,P. G. Natali,Letizia Perracchio,Jelmar Quist,Anita Grigoriadis,Pierfrancesco Marra,Andrew Tutt,Andrew Tutt,M Piantelli,Stefano Iacobelli,V De Laurenzi,Arturo Sala +25 more
TL;DR: It is concluded that the FZD6–fibronectin actin axis identified in this study could be exploited for drug development in highly metastatic forms of breast cancer, such as TNBC.
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Pan-cancer transcriptomic analysis dissects immune and proliferative functions of APOBEC3 cytidine deaminases.
TL;DR: It is demonstrated that A3B expression correlates with cell cycle and DNA repair genes, whereas the other APOBEC3 members display specificity for immune processes and immune cell populations, and the diversification this family of enzymes displays at the transcriptomic level, despite their high similarity in protein sequences and structures.
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Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer
Nirmesh Patel,Daniel Weekes,Konstantinos Drosopoulos,Patrycja Gazinska,Elodie Noel,Mamunur Rashid,Hasan Mirza,Jelmar Quist,Fara Braso-Maristany,Sumi Mathew,Riccardo Ferro,Ana Mendes Pereira,Cynthia Prince,Farzana Noor,Erika Francesch-Domenech,Rebecca Marlow,Emanuele de Rinaldis,Anita Grigoriadis,Spiros Linardopoulos,Pierfrancesco Marra,Andrew Tutt,Andrew Tutt +21 more
TL;DR: The mechanism of addiction to the mitotic kinesin family member C1 (KIFC1/HSET), essential for successful bipolar division of centrosome-amplified malignant cells, is validated and a potential selection biomarker to identify patients with tumors exhibiting Centrosome amplification is developed.
Journal ArticleDOI
Mouse mammary stem cells express prognostic markers for triple-negative breast cancer
Kelly J. Soady,Kelly J. Soady,Howard Kendrick,Qiong Gao,Andrew Tutt,Andrew Tutt,Marketa Zvelebil,Liliana D. Ordonez,Jelmar Quist,Jelmar Quist,David Wei-Min Tan,Clare M. Isacke,Anita Grigoriadis,Anita Grigoriadis,Matthew J. Smalley +14 more
TL;DR: The hypothesis that the biological properties of normal stem cells are drivers of metastasis is supported and these properties can be used to stratify patients with a highly heterogeneous disease such as TNBC.